A new bifunctional squaramide organocatalyst derived from L-proline mediated the first enantioselective synthesis of dihydrospiro[indoline-3,4'-pyrano[2,3-c]pyrazole] derivatives in excellent enantioselectivity by reacting pyrazolones with isatylidine β,γ-unsaturated α-ketoester. This new catalyst outperformed widely used thioureas and squaramides in inducing enantioselectivity.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/acs.orglett.6b00287 | DOI Listing |
Publication Analysis
Top Keywords
enantioselective synthesis
8
synthesis dihydrospiro[indoline-34'-pyrano[23-c]pyrazole]
8
dihydrospiro[indoline-34'-pyrano[23-c]pyrazole] derivatives
8
derivatives michael/hemiketalization
4
michael/hemiketalization reaction
4
reaction bifunctional
4
bifunctional squaramide
4
squaramide organocatalyst
4
organocatalyst derived
4
derived l-proline
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!