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Membrane Trafficking in Neuronal Development: Ins and Outs of Neural Connectivity. | LitMetric

Membrane Trafficking in Neuronal Development: Ins and Outs of Neural Connectivity.

Int Rev Cell Mol Biol

Neuroscience Center and Curriculum in Neurobiology, University of North Carolina, Chapel Hill, NC, United States of America; Department of Cell Biology and Physiology, University of North Carolina, Chapel Hill, NC, United States of America; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, United States of America. Electronic address:

Published: December 2016

AI Article Synopsis

Article Abstract

During development, neurons progress through rapid yet stereotypical shape changes to achieve proper neuronal connectivity. This morphological progression requires carefully orchestrated plasma membrane expansion, insertion of membrane components including receptors for extracellular cues into the plasma membrane and removal and trafficking of membrane materials and proteins to specific locations. This review outlines the cellular machinery of membrane trafficking that play an integral role in neuronal cell shape change and function from initial neurite formation to pathway navigation and synaptogenesis.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4797321PMC
http://dx.doi.org/10.1016/bs.ircmb.2015.10.003DOI Listing

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