Copper/zinc superoxide dismutase (Cu/Zn SOD) is an essential enzyme that protects tissue from oxidative damage. Herein we report the first fluorogenic probe (SODO) for the detection and in vivo imaging of Cu/Zn SOD. SODO represents a unique chemical probe for translational imaging studies of Cu/Zn SOD in inflammatory disorders.
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http://dx.doi.org/10.1039/c6cc00095a | DOI Listing |
Sci Rep
December 2024
Naval Special Medical Center, Naval Medical University, Shanghai, 200433, China.
Superoxide dismutase (SOD) plays important roles in the balance of oxidation and antioxidation in body mostly by scavenging superoxide anion free radicals (O). Previously, we reported a novel Cu/Zn SOD from jellyfish Cyanea capillata, named CcSOD1, which exhibited excellent SOD activity and high stability. TAT peptide is a common type of cell penetrating peptides (CPPs) that efficiently deliver extracellular biomacromolecules into cytoplasm.
View Article and Find Full Text PDFBMC Oral Health
December 2024
Cerrahpaşa Faculty of Medicine, Department of Medical Biochemistry, Istanbul University-Cerrahpaşa, Istanbul, Turkey.
Background: Saliva contains a variety of biochemical compounds, including antioxidants, and serves as the body's first line of defense against oxidative stress caused by free radicals. The aim of this study was to investigate the effects of dental treatments on salivary oxidative stress biomarkers in children aged 3-5 years with severe early childhood caries (S-ECC) compared to children without caries.
Method: This study was conducted on 20 children aged 3-5 years with severe early childhood caries (S-ECC) and 20 children without caries.
Aquat Toxicol
December 2024
Ecological Risk Research Department, Korea Institute of Ocean Science and Technology, Geoje, 53201, South Korea; Department of Ocean Science, Korea University of Science and Technology, Daejeon, 34113, South Korea. Electronic address:
The hull in-water cleaning (IWC) process creates chemical contaminants, including antifouling paint particle mixtures that are directly discharged into the coastal environment. Recent attention has also been paid to the international regulation of ship hull cleaning discharges in environmental media. However, few studies have investigated the adverse effects or toxic pathways on resident marine species.
View Article and Find Full Text PDFAquat Toxicol
January 2025
The Key Laboratory of Water Resources Utilization and Protection of Xiamen, College of Environmental Science and Engineering, Xiamen University of Technology, Xiamen 361024, China.
Both nanoplastic (NP) particles and arsenic (As) are widespread in aquatic environments and pose a combined risk of exposure to aquatic organisms. How the gut of aquatic organisms responds to combined risk of exposure is still unclear. In this study, zebrafish (Danio rerio) were subjected to three distinct As stress environments: only As group (10 μg/L), and As combined with different concentrations of polystyrene (PS) NPs (1 mg/L and 10 mg/L) groups for 21 days via semi-static waterborne exposure.
View Article and Find Full Text PDFInt J Mol Sci
November 2024
College of Animal Science and Technology, Northeast Agricultural University, Harbin 150030, China.
Drought stress affects crop growth and development, significantly reducing crop yield and quality. Alfalfa ( L.), the most widely cultivated forage crop, is particularly susceptible to drought.
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