The role of macrophage-inducible C-type lectin (Mincle) in anti-inflammatory responses has not yet been fully characterized. Herein, we show that engagement of Mincle by trehalose-dimycolate or mycobacteria promotes IL-10 production in macrophages, which causes down-regulation of IL-12p40 secretion. Thus, Mincle mediates both pro- as well as anti-inflammatory responses.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4826952 | PMC |
| http://dx.doi.org/10.1177/1753425916636671 | DOI Listing |
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