Bacterial resistance is a threat to public health. Bacterial biofilm formation is one of the main reasons for persistent infection caused by bacteria. Biofilm development is a complex process that involves many factors and genes which play various roles in all stages of the biofilm formation. This review focuses on the gene regulatory mechanisms relate to the biofilm formation of Staphylococcus, the most common pathogen that causes nosocomial infection, as well as the latest developments of pharmacological anti-biofilm therapies. We also address new strategy to treat bacterial infection and the development of drugs and vaccines against biofilm resistance.
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