We report a review of the morphologic and topographic characteristics of 176 cases of cutaneous fibrous histiocytoma. We confirm its prevalence in females with greater incidence of location in the limbs. Among the morphologic varieties the most frequent is the fibro-collagenous. The most common differential diagnosis comprises dermatofibrosarcoma protuberans, atypical fibroxanthoma, malignant fibrous histiocytomas and idiopathic fibromatosis. Its histogenesis from mesenchymal immature elements and its tendency toward fibrohistiocytic differentiation is generally accepted.
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J Oral Pathol Med
January 2025
Division of Oral and Maxillofacial Pathology, School of Dentistry, University of São Paulo, São Paulo, São Paulo, Brazil.
Background: Melanocytic neoplasms are rare in the oral cavity and represent a diagnostic challenge due to the overlap between benign and malignant lesions. However, their pathogenesis is not fully elucidated. The aim of this study was to evaluate the expression of the cell cycle-related proteins p16, CDK4, and PTEN in oral melanocytic nevi and melanomas.
View Article and Find Full Text PDFAME Case Rep
December 2024
Department of Dermatology, King Fahad Medical City, Riyadh, Saudi Arabia.
Background: Phakomatosis pigmentovascularis (PPV) is a rare congenital cutaneous syndrome characterized by capillary malformation and extensive dermal melanosis. The complexity of PPV is reflected in its evolving classification systems. Systemic manifestations encompass ocular, neurological, vascular, musculoskeletal, and renal involvement.
View Article and Find Full Text PDFAustralas J Dermatol
January 2025
Department of Dermatology, Royal Melbourne Hospital, Parkville, Victoria, Australia.
Cutaneous arteriovenous haemangioma (AVH) is a rare benign vascular lesion, which typically occurs on the head and neck. Its aetiology is unclear but thrombosis, trauma, infection or endocrine triggers have been proposed. We report the case of a 64-year-old female presenting with acquired AVH of the upper lip following oral herpes simplex virus infection.
View Article and Find Full Text PDFAm J Dermatopathol
February 2025
Bioptic Laboratory, Ltd, Pilsen, Czech Republic.
Syphilis, known as "the great mimicker," is caused by the spirochete Treponema pallidum and is characterized by a diverse array of clinical and histopathologic presentations. In secondary cutaneous syphilis, the most consistent morphological features include a superficial and deep perivascular infiltrate containing plasma cells, varying degrees of endothelial swelling, irregular acanthosis, elongation of rete ridges, a vacuolated pattern, and the presence of plasma cells. Although serologic tests are essential for definitive diagnosis, spirochetes can sometimes be directly identified in silver-stained tissue slides or through immunohistochemistry.
View Article and Find Full Text PDFPol J Pathol
January 2025
Department of Dermatology, Medical University of Warsaw, Warsaw, Poland.
Multinucleate cell angiohistiocytoma (MCAH) is a rare benign cutaneous entity. It classically presents as slowly progressive erythematous to violaceous papules on the distal extremities of middle-aged or elderly women. The entity may clinically resemble granuloma annulare, lichen planus, and several cutaneous vascular proliferations.
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