AI Article Synopsis
- The study investigates the relationship between adipokines (adiponectin and leptin) and markers of oxidative stress (MDA-TBARS) in healthy pregnant women versus those with gestational hypertension and pre-eclampsia.
- A significant negative correlation was found between MDA-TBARS and adiponectin levels in healthy pregnancies, indicating that higher oxidative stress is linked to lower adiponectin.
- This relationship is altered in patients with gestational hypertension or pre-eclampsia, suggesting these conditions may disrupt normal antioxidant mechanisms in pregnancy.
Article Abstract
The study of adipokines and oxidative stress has aided in understanding pre-eclampsia physiopathology. Therefore, our group aimed to evaluate the correlation between the adipokines (adiponectin and leptin) and the oxidative stress marker malondialdehyde-thiobarbituric acid reactive substances (MDA-TBARS) and antioxidant activity of plasma [ferric reducing ability of plasma (FRAP)] in healthy pregnant women and patients with gestational hypertension and pre-eclampsia. We found a significant negative correlation between MDA-TBARS and adiponectin (r = -0.40, p = 0.0042), suggesting a relationship between antioxidant levels and this adipokine in healthy pregnancies which is altered in patients with gestational hypertension or pre-eclampsia.
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| http://dx.doi.org/10.3109/08037051.2015.1134550 | DOI Listing |
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