AI Article Synopsis
- Zinc is crucial for immune function, and its deficiency can lead to reduced T cell numbers and weakened immunity, which is particularly significant in the development of pulmonary tuberculosis.
- A study in Bangladesh analyzed serum zinc levels in 50 patients with multidrug-resistant tuberculosis (MDR-TB) and found 76% had zinc levels below the normal range of 70-120 μgm/dl.
- The average serum zinc level was 60.40 μgm/dl, indicating an impaired immune status in these patients, with no significant correlation found between zinc levels and age or sex.
Article Abstract
Zinc plays a vital role in the immune status. Its deficiency affects host defense by reducing the number of circulating T cells and phagocytosis activity of other cells which ultimately impair cell mediated immunity. The cell-mediated immunity plays a major role in the causation of pulmonary tuberculosis. The present study was carried out to estimate serum zinc level in newly detected multidrug resistant tuberculosis (MDR-TB) in adult population. In this study total fifty (50) MDR-TB patients were enrolled conveniently from the in-patients departments of National Institute of Diseases of the Chest Hospital (NIDCH), Bangladesh. Serum zinc was estimated by atomic absorption spectrophotometry method from early morning fasting blood sample. Serum zinc level was assessed according to normal cut-off value 70-120 μgm/dl and 76% studied population were found lower than this value. The mean±SD serum zinc level was observed 60.40±8.91 μgm/dl. No associations were found between serum zinc level with age (p=0.11) and with sex (p=0.085) of the study population respectively. The low level of serum zinc in MDR-TB patients suggested impaired immune status of our study population.
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