Ynol Ethers: Synthesis and Reactivity.

Chimia (Aarau)

Université Grenoble Alpes, Département de Chimie Moléculaire (SERCO), UMR-5250 CNRS, IMCG FR-2607, 38041 Grenoble, France.

Published: April 2016

Ynol ethers are highly valuable substrates offering a wide range of reactivity. These highly electron-rich heterosubstitued alkynes can be of great synthetic potential. In this mini-review, the different methods for the synthesis of ynol ethers are first presented, divided in three main approaches involving a β-elimination, a carbene rearrangement and a direct oxidation of an alkyne. Their reactivity is then summarized underlying their synthetic utility. This non-exhaustive review aims at presenting the intrinsic reactivity of these compounds, still underexploited in synthesis.

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http://dx.doi.org/10.2533/chimia.2016.93DOI Listing

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