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| http://dx.doi.org/10.1590/0100-3984.2015.0071 | DOI Listing |
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Nanoformulated CHO-rPb27 vaccine enhances immunity and controls infection, mitigating lung inflammation and dysfunction during experimental Paracoccidioidomycosis in mice.
Int J Biol Macromol
November 2024
Laboratory of Pulmonary Immunology and Mechanics, Department of Physiology and Biophysics, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil. Electronic address:
Article Synopsis
- * Research is exploring the use of nanotechnology to create new antifungal therapies and vaccines, which can provide targeted delivery and reduce side effects and costs.
- * The study found that the CHO-rPb27 vaccine nanoformulation effectively controls PCM in mice, promoting strong immune responses and reducing tissue damage and lung issues compared to traditional treatment methods.
Histoplasma capsulatum urinary antigen detection in a kidney transplant recipient with acute paracoccidioidomycosis: Case study and literature review.
PLoS Negl Trop Dis
August 2024
Laboratório de Pesquisa Clínica em Dermatologia Infecciosa, Instituto Nacional de Infectologia Evandro Chagas, Fundação Oswaldo Cruz (Fiocruz), Rio de Janeiro, Brazil.
Background: Paracoccidioidomycosis (PCM) and histoplasmosis are endemic fungal diseases in South America. Both can lead to lung involvement with fungal dissemination progressing to systemic and severe clinical manifestations, especially in immunosuppressed hosts. As the population of immunosuppressed individuals has been rising, a higher occurrence of fungal infections is predicted in this setting.
View Article and Find Full Text PDFMDSCs use a complex molecular network to suppress T-cell immunity in a pulmonary model of fungal infection.
Front Cell Infect Microbiol
July 2024
Institute of Science and Technology, Federal University of São Paulo - UNIFESP, São Paulo, Brazil.
Article Synopsis
- Paracoccidioidomycosis (PCM) is a systemic fungal disease found mainly in Latin America, and various immune suppressive mechanisms regulate the host's immune response to it, including tolerogenic dendritic cells and regulatory T-cells.
- This study investigates how receptors like Dectin-1, TLR2, and TLR4 affect the production of immunosuppressive molecules by myeloid-derived suppressor cells (MDSCs) during fungal infections in the lungs.
- Results showed that blocking Dectin-1, TLR2, and TLR4 significantly reduced levels of immunosuppressive molecules such as IL-10 and nitrotyrosine, leading to decreased suppressive activity of MDS
The dark side of T2: central nervous system lesions with low signal intensity on T2-weighted imaging.
Radiol Bras
April 2024
Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil.
Article Synopsis
- * A retrospective analysis was conducted on brain and spine MRI examinations from 2015 to 2022, confirming diagnoses through clinical and histopathological correlation.
- * The cases reviewed included various conditions like arteriovenous malformation and metastatic diseases, demonstrating how T2-weighted imaging profiles contributed to more accurate conclusions about the patients' conditions.
Specific Depletion of Myeloid-Derived Suppressor Cells by the Chemotherapy Agent 5-Fluorouracil Enhances Protective Immune Response in Paracoccidioidomycosis.
J Infect Dis
November 2024
Institute of Science and Technology, Federal University of São Paulo, São José dos Campos, Brazil.
Article Synopsis
- Paracoccidioidomycosis (PCM) is a fungal infection prevalent in Latin America, where certain immune cells (like MDSCs) play a role in suppressing the immune response against the disease.
- Recent findings show that the chemotherapy drug 5-Fluorouracil (5-FU) can effectively reduce MDSCs, leading to improved immune responses and better outcomes in mice infected with the fungus P. brasiliensis.
- The study concludes that using 5-FU to deplete MDSCs could serve as a promising immunotherapy strategy for enhancing immunity against PCM.
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