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Biosimilars: A Critical Review of Development, Regulatory Landscape, and Clinical Implications.
AAPS PharmSciTech
January 2025
School of Pharmaceutical Sciences, Delhi Pharmaceutical Sciences and Research University, New Delhi, India, 110017.
The biopharmaceutical industry has witnessed significant growth in the development and approval of biosimilars. These biosimilars aim to provide cost-effective alternatives to expensive originator biosimilars, alleviating financial pressures within healthcare. The manufacturing of biosimilars is a highly complex process that involves several stages, each of which must meet strict regulatory standards to ensure that the final product is highly similar to the reference biologic.
View Article and Find Full Text PDFCritical Care Challenges and Mortality Predictors in Older Adults: A Comprehensive Cohort Analysis.
Cureus
December 2024
Critical Care, Unidade Local de Saúde de Lisboa Ocidental, Lisbon, PRT.
Purpose: As the population ages, critically ill older adults increasingly face complications and require more healthcare resources during hospitalization. Since post-ICU (intensive care unit) mortality is an important consideration, particularly in elderly populations, this study aims to assess whether advanced age impacts ICU and post-ICU mortality by comparing outcomes between patients aged 81 years and above with those below 81 years.
Methods: This retrospective study analyzed data from 3,821 ICU patients treated at the Unidade Local de Saúde de Lisboa Ocidental between 2015 and 2023.
Assessing the capacity to implement the international health regulations to control COVID-19 at points of entry in Eswatini.
J Infect Dev Ctries
December 2024
Institute of Public Health, College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Introduction: Significant challenges to implementing international health regulations (IHR) at points of entry (PoEs) have been highlighted by the coronavirus disease 2019 (COVID-19) pandemic. Better assessment of the capacities of the PoEs may promote focused interventions. This study aimed to assess the capacities and practices at PoEs.
View Article and Find Full Text PDFNurses' experiences of cross-cultural care encounters in Swedish pediatric hospital care: A qualitative study.
J Pediatr Nurs
January 2025
Department of Neurobiology, Care Sciences and Society, Division of Nursing, Karolinska Institutet, Alfred Nobels Allé 23, 23 300, SE 141 83 Huddinge, Sweden.
Purpose: Nurses are expected to provide appropriate care for children from diverse cultural backgrounds to achieve the aims of current legislation on good care and to ensure equal terms for the entire population. This study aim was to describe nurses' experiences of cross-cultural care encounters when interacting with children and families with a Culturally and Linguistically Diverse background in Swedish pediatric hospital care.
Design And Methods: A descriptive qualitative study was conducted.
From Vision to Reality: The EU's Pharmaceutical Reforms and the Path to Improved Access.
Pharmacoecon Open
January 2025
Department of Health Policy and Medical Technology Research Group, LSE Health, London School of Economics and Political Science, London, UK.
Disparities in access to oncology medicines in European Union (EU) member states can impact patient outcomes profoundly, with availability and timely access varying significantly across and within member states. This paper discusses the intersection of the new European Health Technology Assessment Regulation (HTAR), the provisions of the proposed pharmaceutical legislation and their potential impacts on access to oncology medicines across EU member states. The HTAR, seeking to standardise the clinical evaluation of new medicines, has the potential to streamline the evaluation process but also risks oversimplifying diverse national healthcare needs.
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