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In vitro and in vivo evaluation of tedizolid nanoparticle incorporated buccal films for oromucosal infections.
Int J Pharm
November 2024
Department of Biology, Science Faculty, Ege University, 35100 İzmir, Turkey; Laboratory Animals Research Center, Ege University, 35100 İzmir, Turkey.
Article Synopsis
- A novel formulation of tedizolid phosphate (TZP) nanoparticle-loaded buccal films was developed to treat buccal wounds infected with Staphylococcus aureus.
- The optimal nanoparticle (NP) formulation was characterized and incorporated into mucoadhesive buccal films, demonstrating effective antibacterial properties in both in vitro and in vivo studies.
- The study found that the TZP-NP-loaded films significantly reduced bacterial counts and effectively inhibited S. aureus growth in wound samples, indicating their potential for long-lasting antibacterial treatment of buccal wounds.
Antimicrobial Effect of Oxazolidinones and Its Synergistic Effect with Bedaquiline Against Complex.
Infect Drug Resist
January 2023
Clinical Center on Tuberculosis Control, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Institute, Beijing, People's Republic of China.
Purpose: Unsatisfactory efficacies of currently recommended anti- complex (MABC) treatment regimens have led to development of novel drugs to combat MABC infections. In this study, we evaluated in vitro antimicrobial activities of bedaquiline (BDQ) and four oxazolidinones against MABC isolates.
Methods: The resazurin microplate assay was performed to determine minimum inhibitory concentrations (MICs) of BDQ and four oxazolidinones, including tedizolid (TZD), sutezolid (SZD), delpazolid (DZD), and linezolid (LZD), against 65 MABC isolates.
Cost of off-label antibiotic therapy for bone and joint infections: a 6-year prospective monocentric observational cohort study in a referral centre for management of complex osteo-articular infections.
J Bone Jt Infect
September 2021
Infectious Diseases Department, Croix-Rousse Hospital, Hospices Civils de Lyon, 69004 Lyon, France.
: Costs related to bone and joint infection (BJI) management are increasing worldwide, particularly due to the growing use of off-label antibiotics that are expensive treatments (ETs), in conjunction with increasing incidence of multi-drug-resistant pathogens. The aim of this study was to evaluate the whole costs related to these treatments during the patient route, including those attributed to the rehabilitation centre (RC) stay in one regional referral centre in France. The total annual cost of ETs for managing complex BJIs in France was then estimated.
View Article and Find Full Text PDFLate-stage oxidative C(sp)-H methylation.
Nature
April 2020
Department of Chemistry, Roger Adams Laboratory, University of Illinois, Urbana, IL, USA.
Frequently referred to as the 'magic methyl effect', the installation of methyl groups-especially adjacent (α) to heteroatoms-has been shown to dramatically increase the potency of biologically active molecules. However, existing methylation methods show limited scope and have not been demonstrated in complex settings. Here we report a regioselective and chemoselective oxidative C(sp)-H methylation method that is compatible with late-stage functionalization of drug scaffolds and natural products.
View Article and Find Full Text PDFHypertensive crisis following the administration of tedizolid: possible serotonin syndrome.
Eur J Hosp Pharm
January 2020
Department of Pharmacy, Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí I3PT. Universitat Autònoma de Barcelona, Sabadell, Barcelona, Spain.
Thiscase report concerns a 34-year-old male with a hip prosthesis infection, under treatment with antidepressant and antihypertensive drugs, who presented with an increase in blood pressure after four days of treatment with oral tedizolid. Tedizolid was discontinued, and the dose of antihypertensive was increased. The patient progressively achieved the normalisation of blood pressure values, which allowed a reduction in the antihypertensive agent dose to its usual regimen.
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