Polymorphism in phenobarbital: discovery of a new polymorph and crystal structure of elusive form V.

Chem Commun (Camb)

Department of Chemistry, University of Michigan, Ann Arbor, Michigan 48109-1055, USA. and Macromolecular Science and Engineering, University of Michigan, 48109-1055, USA.

Published: March 2016

This report highlights the discovery of a new polymorph of the anticonvulsant drug phenobarbital (PB) using polymer-induced heteronucleation (PIHn) and unravelling the crystal structure of the elusive form V. Both forms are characterized by structural, thermal and VT-Raman spectroscopy methods to elucidate phase transformation behavior and shed light on stability relationships.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4964875PMC
http://dx.doi.org/10.1039/c6cc00959jDOI Listing

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