AI Article Synopsis
- Akabane virus (AKAV) is a significant pathogen in ruminants, causing abortions and congenital defects, yet it has not been thoroughly explored in Nigeria.
- A study in southwest Nigeria found a high seropositivity rate of 70.1% in cattle and a lower rate of 4.3% in sheep, with varying positivity across different age groups.
- The presence of antibodies in unvaccinated animals highlights the need for ongoing monitoring and awareness to manage and control AKAV effectively in the region.
Article Abstract
Akabane virus (AKAV) is recognized as an important pathogen that causes abortions and congenital malformations in ruminants. However, it has not received adequate attention in Nigeria. Therefore, in investigating this disease, serum samples from 184 (abattoir and farm) head of cattle and 184 intensively reared sheep from two states in southwest Nigeria were screened for antibodies against AKAV using enzyme-linked immunosorbent assay. An overall seropositivity of 70.1% (129/184) was obtained with antibodies being detectable in 73.8% of abattoir (trade) cattle and 40.0% in farm cattle, while 4.3% (8/184) seropositivity was observed in sheep. All the age groups of cattle tested had seropositive animals, 0-1 year (1/7, 14.3%), 2-3 years (17/34, 50.0%), 4-5 years (92/121, 76.0%), and >5 years (19/22, 86.4%), while in sheep only the age groups of 2-3 and 4-5 years showed seropositivity of 4.1% (4/97) and 8.2% (4/49), respectively. The detection of antibody-positive animals among unvaccinated cattle and sheep provides evidence of AKAV infection in Nigeria. These findings call for continuous monitoring of the disease among ruminants in order to ascertain the actual burden and increase awareness of the disease. This will facilitate early detection and aid the development of appropriate control measures against the disease in Nigeria.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4746297 | PMC |
| http://dx.doi.org/10.1155/2016/2936082 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Hepatitis C-positive grafts for hepatitis C-negative recipients in liver transplantation: Buried treasure or depleting resource?
Liver Transpl
December 2024
Division of Abdominal Transplant, Department of Surgery, Stanford University, Stanford, California, USA.
Long-term outcomes of using hepatitis C virus (HCV) positive donors in HCV-negative recipients in liver transplantation (LT) are not well established. Data from the United Network for Organ Sharing (UNOS) database between July 1, 2015, and December 31, 2023, were analyzed. The cohort included 44,447 HCV antibody-negative (Ab-) candidates who underwent deceased donor LT.
View Article and Find Full Text PDFDirect TaqMan assay for the detection and genotyping of bovine viral diarrhea virus types 1 and 2.
Arch Virol
December 2024
Center for Animal Disease Control, University of Miyazaki, Miyazaki, 889-2192, Japan.
Bovine viral diarrhea (BVD), caused by bovine viral diarrhea virus (BVDV), has a significant economic impact on affected farms worldwide. For effective disease control, it is crucial to select an appropriate vaccine based on the specific genotype of BVDV. Therefore, developing a rapid and reliable assay to detect and genotype BVDV is imperative for controlling the spread of disease.
View Article and Find Full Text PDFViromics-based precision diagnosis of reproductive abnormalities in cows reveals a reassortant Akabane disease virus.
BMC Vet Res
November 2024
Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, Jilin Province, China.
Background: At the end of 2021, an epidemic of reproductive abnormalities in cows occurred in Jilin Province, China, posing an urgent need for a rapid diagnosis.
Results: To identify the cause of the disease, a total of 172 samples were collected from 21 dead calves and 45 aborting or pregnant cows in 10 farms across the province. Routine PCR or RT-PCR detection did not find any common abortion-related agents.
Bioluminescent and fluorescent reporter-expressing recombinant Akabane virus (AKAV): an excellent tool to dissect viral replication.
Front Microbiol
November 2024
State Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China.
Article Synopsis
- The Akabane virus (AKAV) is an arbovirus that mainly affects livestock and causes severe congenital abnormalities.
- Researchers developed a reverse genetics system for AKAV, creating recombinant viruses (rAKAV-Nluc and rAKAV-mWasabi) that produce luminescent indicators for studying the virus.
- The study showed that these recombinant viruses maintain similar growth characteristics to the original virus, allowing for further investigation into AKAV's virulence and the range of cell types it can infect.*
Identification of NECTIN1 as a novel restriction factor for flavivirus infection.
mBio
December 2024
State Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China.
Article Synopsis
- NECTIN1 is a cell adhesion molecule known mainly for its interaction with herpesviruses, but this study reveals its new role as a barrier against flavivirus infections, specifically BVDV.
- The researchers found that reducing NECTIN1 levels increased BVDV infections and identified NECTIN1's IgV domain as crucial for its inhibiting function, affecting how BVDV attaches to cells.
- The study also showed NECTIN1’s broader antiviral activity against several other viruses, highlighting its potential significance as a restriction factor in controlling flavivirus infections.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!