AI Article Synopsis
- - Aquaporin 1 (AQP1) is a protein found in endothelial cells that helps manage water flow and is crucial for various bodily functions.
- - The study investigated how the Mef2c protein regulates AQP1 gene expression in endothelial cells by working together with Sp1 to enhance transcription.
- - Results showed that increasing levels of Mef2c and Sp1 led to better migration and formation of structures in endothelial cells, effects that were reversed when AQP1 was knocked down, signifying AQP1's important role in blood vessel formation.
Article Abstract
Aquaporin 1 (AQP1) is expressed in most microvasculature endothelial cells and forms water channels that play major roles in a variety of physiologic processes. This study aimed to delineate the transcriptional regulation of AQP1 by Mef2c in endothelial cells. Mef2c cooperated with Sp1 to activate human AQP1 transcription by binding to its proximal promoter in human umbilical cord vein endothelial cells (HUVEC). Over-expression of Mef2c, Sp1, or Mef2c/Sp1 increased HUVEC migration and tube-forming ability, which can be abolished AQP1 knockdown. These data indicate that AQP1 is a direct target of Mef2c in regulating angiogenesis and vasculogenesis of endothelial cells.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4844935 | PMC |
| http://dx.doi.org/10.14348/molcells.2016.2223 | DOI Listing |
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