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Incorporating immune checkpoint inhibitors in epithelial ovarian cancer.
Gynecol Oncol
January 2025
GOG Foundation, Florida Cancer Specialists and Research Institute, West Palm Beach, FL 33401, United States of America. Electronic address:
Objective: Therapeutic interventions for epithelial ovarian cancer (EOC) have increased greatly over the last decade but improvements outside of biomarker selected therapies have been limited. There remains a pressing need for more effective treatment options that can prolong survival and enhance the quality of life of patients with EOC. In contrast to the significant benefits of immunotherapy with immune checkpoint inhibitors (CPI) seen in many solid tumors, initial experience in EOC suggests limited efficacy of CPIs monotherapy.
View Article and Find Full Text PDFGuarding Drinking Water Safety against Harmful Algal Blooms: Could UV/Cl Treatment Be the Answer?
Environ Sci Technol
January 2025
Environmental Engineering and Science, Department of Chemical and Environmental Engineering (ChEE), University of Cincinnati, Cincinnati, Ohio 45221, United States.
Frequent and severe occurrences of harmful algal blooms increasingly threaten human health by the release of microcystins (MCs). Urgent attention is directed toward managing MCs, as evidenced by rising HAB-related do not drink/do not boil advisories due to unsafe MC levels in drinking water. UV/chlorine treatment, in which UV light is applied simultaneously with chlorine, showed early promise for effectively degrading MC-LR to values below the World Health Organization's guideline limits.
View Article and Find Full Text PDFFrom intelligence to achievement: the role of the socio-cultural environment of underrepresented minority students.
Front Psychol
December 2024
Department of Psychology, University of North Florida, Jacksonville, FL, United States.
The role of mitochondria in aging, cell death, and tumor immunity.
Front Immunol
January 2025
Department of Medicine, University of Florida (UF) Health Cancer Center, University of Florida, Gainesville, FL, United States.
Mitochondria are essential double-membrane organelles with intricate structures and diverse functions within cells. Under normal physiological conditions, mitochondria regulate cellular metabolism and maintain energy homeostasis via the electron transport chain, mediate stem cell fate, and modulate reactive oxygen species production, playing a pivotal role in energy supply and lifespan extension. However, mitochondrial dysfunction can lead to various pathological changes, including cellular aging, necrosis, dysregulated tumor immunity, and the initiation and progression of cancer.
View Article and Find Full Text PDFCorrigendum to "Image-guided superficial radiation therapy has superior 2-year recurrence probability to Mohs micrographic surgery" [Clin. Transl. Radiat. Oncol. 43 (2023) 100678].
Clin Transl Radiat Oncol
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Cleveland Clinic, Dept of Quantitative Health Sciences, Mail Code JJN3, 9500 Euclid Avenue, Cleveland, OH 44195, United States.
[This corrects the article DOI: 10.1016/j.ctro.
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