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Discovery of novel sesquistilbene indanone analogues as potent anti-inflammatory agents. | LitMetric

Discovery of novel sesquistilbene indanone analogues as potent anti-inflammatory agents.

Eur J Med Chem

Department of Natural Products Chemistry, School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai 201203, China; Shanghai Key Laboratory of Clinical Geriatric Medicine, 221 West Yanan Road, Shanghai 200040, China. Electronic address:

Published: May 2016

AI Article Synopsis

Article Abstract

To develop novel anti-inflammatory agents with improved pharmaceutical profiles, twenty-eight novel sesquistilbene indanone analogues were synthesized and evaluated for anti-inflammatory activity using RAW264.7 cells. Among these compounds, compound 11k was found to be one of the most potent analogues in inhibiting NO production in LPS-stimulated RAW264.7 cells. Furthermore, it could also significantly suppress LPS-induced iNOS and COX-2 expression and NO production through TLR4/JNK/NF-κB signaling pathway in a concentration dependent manner.

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Source
http://dx.doi.org/10.1016/j.ejmech.2016.02.021DOI Listing

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