The skin can serve as an interstitial Na reservoir. Local tissue Na accumulation increases with age, inflammation and infection. This increased local Na availability favors pro-inflammatory immune cell function and dampens their anti-inflammatory capacity. In this review, we summarize available data on how NaCl affects various immune cells. We particularly focus on how salt promotes pro-inflammatory macrophage and T cell function and simultaneously curtails their regulatory and anti-inflammatory potential. Overall, these findings demonstrate that local Na availability is a promising novel regulator of immunity. Hence, the modulation of tissue Na levels bears broad therapeutic potential: increasing local Na availability may help in treating infections, while lowering tissue Na levels may be used to treat, for example, autoimmune and cardiovascular diseases.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5203836 | PMC |
| http://dx.doi.org/10.1007/s00467-016-3349-x | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Chapter 9: INDICATIONS FOR TREATMENT.
Ann Endocrinol (Paris)
January 2025
Endocrinology, Diabetology and Nutrition Department, CHU Larrey, 24 chemin de Pouvourville, TSA 30030, 31059 Toulouse, France. Electronic address:
The choice of therapeutic method for the management of primary hyperparathyroidism depends on the severity of the disease and its complications at the time of diagnosis, the specific situation of each patient and his/her natural history, and assessment of the risk/benefit ratio for each method (surgery, local destruction or drugs). This chapter summarizes the indications for the treatment of primary hyperparathyroidism, based on the international literature available as of December 31, 2023.
View Article and Find Full Text PDFNavigating the referral boundaries for organ and tissue donation: An interpretive description study.
Aust Crit Care
January 2025
School of Nursing, College of Health and Medicine, University of Tasmania, Private Bag 132, Hobart, Tasmania 7001, Australia.
Background: The gap between organ availability and the number of people waiting for a transplant remains a major healthcare issue. Most transplanted organs and tissue are received from donors who have died in intensive care units (ICUs). To increase the number of donors, national guidelines and professional bodies in Australia support routine consideration of organ and tissue donation at the end of life.
View Article and Find Full Text PDFTemporal dynamics of airborne fungi in Swedish forest nurseries.
Appl Environ Microbiol
January 2025
Department of Forest Mycology and Plant Pathology, Uppsala BioCenter, Swedish University of Agricultural Sciences, Uppsala, Sweden.
In Sweden, reforestation of managed forests relies predominantly on planting nursery-produced tree seedlings. However, the intense production using containerized cultivation systems (e.g.
View Article and Find Full Text PDFA proposal on bird focal species selection for higher tier risk assessments of plant protection products in the EU.
Integr Environ Assess Manag
January 2025
tier3 solutions GmbH, Leverkusen, Germany.
The revised EFSA 2023 Guidance on the risk assessment of plant protection products for birds and mammals emphasises vulnerability as a relevant criterion for focal species (FS) selection rather than prevalence. The EFSA 2023 Guidance suggests to rank FS candidates for each dietary group according to their expected exposure by estimating a species-specific daily dietary dose (DDD). Species experiencing higher exposure would be ranked as potentially more vulnerable and can be identified as FS candidates.
View Article and Find Full Text PDFThe role of stereotactic magnetic resonance-guided adaptive radiation therapy (SMART) in locally advanced and borderline resectable pancreatic cancer.
Ann Transl Med
December 2024
Department of Clinical Oncology, The Christie NHS Foundation Trust, Manchester, UK.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!