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Review of Applications of Microneedling in Melasma.
J Cosmet Dermatol
January 2025
Department of Dermatology, Peking University Shenzhen Hospital, Shenzhen, China.
Background: Melasma, a common skin pigmentation disease, can negatively impact patients' mental health, social interactions, and physical appearance. Although we now have several treatments accessible, such as medicines, chemical peels, and phototherapy, which can help ease symptoms to some extent, the requirement for a long-term effective and safe treatment for patients is far from met. In the face of this problem, microneedling, as an innovative treatment, provides a new avenue for treating melasma.
View Article and Find Full Text PDF[Topical issues of early diagnosis of hearing loss in newborn children].
Vestn Otorinolaringol
December 2024
Mendeleev Russian University of Chemical Technology, Moscow, Russia.
A group of Russian specialists dealing with the problems of auditory function in premature babies touches upon important issues of early detection of hearing loss and deafness in this contingent of children born before the date of physiological birth. The purpose of the article was to argue the need for a personalized approach to the diagnosis of auditory function in premature and full-term babies depending on the timing of gestation and their somatic state at the time of birth, as well as the comprehensive rehabilitation of children with hearing loss and deafness. The article describes the advantages of the previously developed computer program Multiplicity of audiological monitoring in children of the first year of life with risk factors for hearing loss and deafness.
View Article and Find Full Text PDFMolecular Design and Nanoarchitectonics of Inorganic-Organic Hybrid Sol-Gel Systems for Antifouling Coatings.
Gels
November 2024
Institut für Anorganische Chemie, TU Bergakademie Freiberg, 09596 Freiberg, Germany.
Environmental protection, especially fouling protection, is a very topical and wide-ranging issue. This review explores the development, molecular design, and nanoarchitectonics of sol-gel-based hybrid coatings for antifouling applications. These coatings combine inorganic and organic materials, offering enhanced stability and adaptability, making them ideal for protecting surfaces from fouling.
View Article and Find Full Text PDFAdaptive remodeling of rat adrenomedullary stimulus-secretion coupling in a chronic hypertensive environment.
Cell Mol Life Sci
December 2024
Univ Angers, INSERM, CNRS, MITOVASC, Équipe CARME, SFR ICAT, F-49000 Angers, France.
Chronic elevated blood pressure impinges on the functioning of multiple organs and therefore harms body homeostasis. Elucidating the protective mechanisms whereby the organism copes with sustained or repetitive blood pressure rises is therefore a topical challenge. Here we address this issue in the adrenal medulla, the master neuroendocrine tissue involved in the secretion of catecholamines, influential hormones in blood pressure regulation.
View Article and Find Full Text PDFCarvacrol/cyclodextrin/ceria nanoparticle/hyaluronate hybrid microneedle for promoted diabetic wound healing through the modulation of microenvironment.
Int J Biol Macromol
December 2024
School of Biomedical Engineering and Medical Imaging, Army Medical University, Chongqing 400038, China. Electronic address:
Article Synopsis
- Delayed healing in diabetic wounds is primarily due to a dysfunctional microenvironment caused by high blood sugar and ongoing inflammation.
- Topical microenvironment modulation, particularly using microneedles, offers a promising solution to enhance healing by delivering therapeutic agents directly to the wound's surface.
- A hybrid microneedle has been developed incorporating carvacrol, cyclodextrin, mesoporous ceria nanoparticles, and hyaluronate, which improves healing by providing antibacterial, antioxidant, and anti-inflammatory effects to accelerate tissue reconstruction processes like cell proliferation and angiogenesis.
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