AI Article Synopsis

  • The study aimed to assess if sulfur hexafluoride (SF6) gas is as effective as longer-acting gases in macular hole surgery, and whether not positioning face-down after surgery affects outcomes.* -
  • Conducted as a nonrandomized observational cohort study, it involved 2456 eyes from 2367 patients who underwent surgery for idiopathic macular holes, collecting data on demographics, surgical procedures, and outcomes.* -
  • Results showed a 95% closure rate for macular holes, with SF6 proving noninferior to longer gases. While not using face-down positioning was generally effective, its effectiveness was uncertain for larger holes (>400 μm in diameter).*

Article Abstract

Purpose: To determine whether sulfur hexafluoride (SF6) gas is noninferior to longer-acting gases in macular hole surgery and whether withholding postoperative face-down positioning (FDP) is noninferior to FDP.

Design: Registry-style, prospective, nonrandomized, observational cohort study.

Participants: Patients with idiopathic macular holes undergoing primary surgery.

Methods: Surgeons were invited to submit clinical details of all macular hole cases receiving surgery. Baseline demographic and clinical information were collected, as well as details of surgical intervention and postoperative posturing advice. Primary follow-up data were collected 3 months postoperatively.

Main Outcome Measures: Macular hole closure at 3 months. A noninferiority approach was used, with a noninferiority margin set at 5% decreased frequency of success.

Results: A total of 2456 eyes of 2367 patients were included in the study. Outcomes were available in 94.9% of cases (2330/2456). The rate of macular hole closure was 95.0% (2214/2330). Sulfur hexafluoride gas was found to be noninferior to longer-acting gases (95% confidence interval [CI] for adjusted effect on success, -1.76 to +2.25), and noninferiority was demonstrated regardless of macular hole size. Although withholding FDP was found to be noninferior to FDP for the study population as a whole (95% CI for adjusted effect on success, -4.21 to +0.64), the result was inconclusive in holes >400 μm in diameter (95% CI, -9.31 to +1.04). Lack of internal limiting membrane (ILM) peel, increasing hole size, hole duration ≥9 months, increasing age, and 20-gauge surgery all were associated with lower odds of success. Vitreous attachment to the hole margin was not associated with outcome when corrected for hole size, and combined phacovitrectomy surgery was not observed to affect the odds of success in phakic eyes.

Conclusions: Sulfur hexafluoride gas tamponade was noninferior to longer-acting gases in the surgical management of macular hole. Withholding FDP was noninferior to FDP in holes ≤400 μm in diameter. In holes >400 μm in diameter, noninferiority of withholding FDP could not be concluded. We would advise caution if posturing is withheld in this group on the basis of the results of this study and of others.

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Source
http://dx.doi.org/10.1016/j.ophtha.2015.12.039DOI Listing

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