AI Article Synopsis
- Transgenic models have advanced our understanding of neurodegenerative diseases, but issues like protein overexpression and systemic compensation have led researchers to explore more natural models.
- Natural models, especially rodents, are being reviewed for their ability to display key biomarkers associated with aging-related neurodegenerative diseases.
- The focus is on genetic variations in biomarkers for Alzheimer's disease and how these relate to genetic variants seen in humans suffering from the disease.
Article Abstract
The use of transgenic models for the study of neurodegenerative diseases has made valuable contributions to the field. However, some important limitations, including protein overexpression and general systemic compensation for the missing genes, has caused researchers to seek natural models that show the main biomarkers of neurodegenerative diseases during aging. Here we review some of these models-most of them rodents, focusing especially on the genetic variations in biomarkers for Alzheimer diseases, in order to explain their relationships with variants associated with the occurrence of the disease in humans.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4769573 | PMC |
| http://dx.doi.org/10.1186/s40659-016-0072-9 | DOI Listing |
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