Multigrowth Factor Delivery via Immobilization of Gene Therapy Vectors.

Adv Mater

Department of Periodontics and Oral Medicine and Department of Biomedical Engineering, University of Michigan, 1011 North University Avenue, Ann Arbor, MI, 48109-1078, USA.

Published: April 2016

Molecules can be immobilized onto biomaterials by a chemical vapor deposition (CVD) coating strategy. Pentafluorophenolester groups react with amine side chains on antibodies, which can selectively immobilize adenoviral vectors for gene delivery of growth factors. These vectors can produce functional proteins within defined regions of biomaterials to produce customizable structures for targeted tissue regeneration.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5687504PMC
http://dx.doi.org/10.1002/adma.201600027DOI Listing

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