Background: Incisional hernias occur in about ten percent of patient after elective abdominal operations. Although over 100,000 are performed annually in this country, the best method of repair remains controversial. We report the outcomes after a standardized approach by one surgeon.
Methods: The operation consisted of placement of polypropylene mesh beneath the fascia with fascial closure. A prospective database was maintained for the time period January, 1995, to June, 2014. All patients were followed for a minimum of six months postoperatively.
Results: There were 538 patients with a mean body mass index of 36.2 kg/m(2) and a mean defect size of 134.5 cm(2). There were 292 primary hernias with a recurrence rate of 2.7% and 246 recurrent hernias with a recurrence rate of 4.1% (P = .47). There was one death (.2%). Forty-three patients (8.0%) developed a wound complication, of which 17 (3.2%) were infections and the rest seromas. Only two patients required removal of the mesh. There were six patients admitted for postoperative small bowel obstruction, but only one in the immediate postoperative period. There were two enterocutaneous fistulas, both of which resolved nonoperatively. Five patients developed nonfatal pulmonary emboli. Mean length of stay decreased from an average of 4.0 days for the first 100 patients to 2.8 days for the subsequent patients.
Conclusions: Retrofascial mesh repair for ventral incisional hernias has both low complication and recurrence rate. It should be considered the gold standard for such repairs.
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http://dx.doi.org/10.1016/j.amjsurg.2015.12.004 | DOI Listing |
Curr Med Chem
January 2025
Department of Biochemistry, J.N. Medical College, Faculty of Medicine, Aligarh Muslim University, Aligarh, India.
Ovarian cancer (OC) ranks as the fifth leading cause of cancer-related deaths in the United States, posing a significant threat to female health. Late-stage diagnoses, driven by elusive symptoms often masquerading as gastrointestinal issues, contribute to a concerning 70% of cases being identified in advanced stages. While early-stage OC brags a 90% cure rate, progression involving pelvic organs or extending beyond the peritoneal cavity drastically diminishes it.
View Article and Find Full Text PDFCirc Cardiovasc Qual Outcomes
January 2025
Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor. (C.C., L.B.M., L.D.L.).
Background: Few population-based studies have assessed sex differences in stroke recurrence. In addition, contributors to sex differences in recurrence and poststroke mortality, including social factors, are unclear. We investigated sex differences in these outcomes and the contribution of social, clinical, and behavioral factors to the sex differences.
View Article and Find Full Text PDFExp Ther Med
February 2025
Department of Histopathology, Specialty Hospital, Amman 11194, Jordan.
In the present case, a 66-year-old woman presented to the Specialty Hospital (Amman, Jordan) with recurrent post-menopausal bleeding. A pelvic ultrasound scan showed an abnormal endometrial thickness of 8 mm and no adnexal masses. An endometrial biopsy revealed abundant foamy histiocyte infiltration features suggestive of xanthogranulomatous endometritis.
View Article and Find Full Text PDFJ Immunother Precis Oncol
February 2025
TopAlliance Biosciences Inc. Rockville, MD, USA.
Introduction: This was the first phase 1 study conducted in the United States. It consisted of dose-escalation (part A) and multiple indication-specific cohort expansion (part B), investigating the safety and preliminary efficacy of toripalimab (anti-programmed cell death-1 inhibitor) in patients with advanced malignancies.
Methods: Patients with advanced malignancies that progressed after treatment with at least one prior line of standard systemic therapy, including the patients with advanced/recurrent cholangiocarcinoma (CCA), received toripalimab 240 mg every 3 weeks in part B.
Cureus
December 2024
Department of Cardiology, Geetanjali Medical College and Hospital, Udaipur, IND.
Background Carotid artery stenting is a well-established alternative treatment to carotid endarterectomy for carotid artery stenosis for preventing stroke. This study assessed the procedural and clinical outcomes in patients undergoing carotid artery stenting in a tertiary care center in India. Methods A total of 39 patients underwent carotid artery stenting from January 2022 to December 2023, with different embolic protection devices and carotid stents.
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