AI Article Synopsis
- Growth-retarded mouse (grt/grt) is a model for studying primary congenital hypothyroidism due to TSH signaling resistance.
- Researchers used ex vivo CT scans to assess the cerebral cortex and found significant volume reduction in the parietal region of grt/grt mice, particularly affecting the somatosensory cortex.
- The findings suggest that cortical hypoplasia patterns in grt/grt mice align with those observed in human cases of congenital hypothyroidism.
Article Abstract
Growth-retarded mouse (grt/grt) is a spontaneous mutant that is known as an animal model for primary congenital hypothyroidism caused by resistance to TSH signaling. The regional pattern of cerebral cortical hypoplasia was characterized in grt/grt mice. Ex vivo computed tomography (CT)-based volumetry was examined in four regions of the cerebral cortex, i.e., prefrontal, frontal, parietal and occipito-temporal regions, which were demarcated by structural landmarks on coronal CT images. A region-specific reduced volume of the parietal cortical region covering most of the somatosensory cortex was noted in grt/grt mice rather than in both heterozygous (grt/+) and wild-type (+/+) mice. We concluded that the cortical hypoplasia in grt/grt was seen in identical cortical regions corresponding to human congenital hypothyroidism.
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| http://dx.doi.org/10.1111/cga.12161 | DOI Listing |
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