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Autoantibodies Targeting G-Protein-Coupled Receptors and RAS-Related Molecules in Post-Acute COVID Vaccination Syndrome: A Retrospective Case Series Study.
Biomedicines
December 2024
Unit of Epidemiology & Statistical Medicine, Department of Diagnostics and Public Health, University of Verona, 37134 Verona, Italy.
: While post-acute COVID-19 syndrome is well known and extensively studied, the post-acute COVID vaccination syndrome (PACVS) is a more recent nosological entity that is poorly defined at the immunopathological level, although it shares many symptoms with the sequelae of viral infections. : This single-center retrospective study reports a case series of 17 subjects vaccinated with mRNA or adenoviral vector vaccines who were healthy before vaccination and had never been infected with SARS-CoV-2 but who presented with symptoms similar to PACVS for a median time of 20 months (min 4, max 32). The medical records of all patients referred to our outpatient clinic over a one-year period were retrospectively analyzed.
View Article and Find Full Text PDFAn integral renewal equation approach to behavioural epidemic models with information index.
J Math Biol
December 2024
National Research Council of Italy, Institute for Computational Application "M. Picone", Via P. Castellino 111, 80131, Naples, Italy.
We propose an integral model describing an epidemic of an infectious disease. The model is behavioural in the sense that the force of infection includes the information index that describes the opinion-driven human behavioural changes. The information index contains a memory kernel to mimic how the individuals maintain memory of the past values of the infection.
View Article and Find Full Text PDFAcute kappa opioid receptor blocking disrupts the pro-cognitive effect of cannabidiol in neuropathic rats.
Neuropharmacology
December 2024
Department of Experimental Medicine, Division of Pharmacology, Università della Campania "L. Vanvitelli", Naples, Italy.
Cannabidiol has been shown to ameliorate neuropathic pain and its affective components. Previous studies highlighted the pharmacological interaction between the CBD and opioid system, particularly the MOR, but the understanding of the interaction between CBD and kappa opioid receptor (KOR), physiologically stimulated by the endogenous opioid dynorphin, remains elusive. We assessed the pharmacological interactions between CBD and nor-BNI, a selective KOR antagonist in a rat neuropathic pain model.
View Article and Find Full Text PDFBilingualism, sleep, and cognition: An integrative view and open research questions.
Brain Lang
January 2025
Adger University, Kristiansand, Norway.
Sleep and language are fundamental to human existence and have both been shown to substantially affect cognitive functioning including memory, attentional performance, and cognitive control. Surprisingly, there is little-to-no research that examines the shared impact of bilingualism and sleep on cognitive functions. In this paper, we provide a general overview of existing research on the interplay between bilingualism and sleep with a specific focus on executive functioning.
View Article and Find Full Text PDFTransdermal delivery of PeptiCRAd cancer vaccine using microneedle patches.
Bioact Mater
March 2025
Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, FI-00014, Helsinki, Finland.
Microneedles (MNs) are a prospective system in cancer immunotherapy to overcome barriers regarding proper antigen delivery and presentation. This study aims at identifying the potential of MNs for the delivery of Peptide-coated Conditionally Replicating Adenoviruses (PeptiCRAd), whereby peptides enhance the immunogenic properties of adenoviruses presenting tumor associated antigens. The combination of PeptiCRAd with MNs containing polyvinylpyrrolidone and sucrose was tested for the preservation of structure, induction of immune response, and tumor eradication.
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