Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/exd.12995 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Itaconate drives pro-inflammatory responses through proteasomal degradation of GLO1.
Biochem Biophys Res Commun
January 2025
2nd Ward of Oncology Department, China-Japan Union Hospital of Jilin University, Changchun, Jilin, 130031, China. Electronic address:
Itaconate is a small-molecule metabolite generated by the enzyme aconitate decarboxylase 1 (ACOD1), which is upregulated during inflammation. Traditionally, itaconate has been recognized for its anti-inflammatory properties; however, this study reveals a pro-inflammatory mechanism of itaconate in macrophages. We demonstrate that itaconate promotes the proteasomal degradation of glyoxalase 1 (GLO1) via Cys139.
View Article and Find Full Text PDFInvestigating the Role of Glyoxalase 1 as a Therapeutic Target for Cocaine and Oxycodone Use Disorder.
bioRxiv
December 2024
Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Methylglyoxal (MG) is an endogenously produced non-enzymatic side product of glycolysis that acts as a partial agonist at GABA receptors. MG that is metabolized by the enzyme glyoxalase-1 (GLO1). Inhibition of GLO1 increases methylglyoxal levels, and has been shown to modulate various behaviors, including decreasing seeking of cocaine-paired cues and ethanol consumption.
View Article and Find Full Text PDFCombined effects of a pharmaceutical pollutant, gemfibrozil, and abiotic stressors (warming and air exposure) on cellular stress responses of the blue mussels Mytilus edulis.
Aquat Toxicol
January 2025
Department of Marine Biology, Institute for Biological Sciences, University of Rostock, Rostock, Germany; Department of Maritime Systems, Interdisciplinary Faculty, University of Rostock, Rostock, Germany. Electronic address:
Lipid-lowering drugs such as gemfibrozil (GFB) are widely used and highly biologically active, contributing to their persistence in wastewater and subsequent release into aquatic ecosystems. However, the potential impacts and toxic mechanisms of these emerging pollutants on non-target marine organisms, particularly keystone bivalves like Mytilus edulis, remain poorly understood. To address this knowledge gap, we investigated the effects of environmentally relevant concentrations of GFB (25 µg l) on oxidative, nitrosative, and dicarbonyl stress in M.
View Article and Find Full Text PDFExogenous Treatment of Caffeic Acid and Methylglyoxal Synergistically Enhances Anticancer Effect in Prostate Cancer via Inhibition of Glyoxalase-1.
Prostate
January 2025
Radiation and Cancer Therapeutics Lab, School of Life Sciences, Jawaharlal Nehru University, New Delhi, India.
Background: Caffeic acid (CA), a dietary compound, has been studied for its potential impact on inhibiting prostate cancer (PCa) growth. PCa is often associated with heightened expression of glyoxalase-1 (Glo-1), making it a target for potential therapeutic interventions. CA's mechanisms in suppressing Glo-1 expression and its effects on PCa cell proliferation are areas of interest for understanding its potential as an anticancer agent.
View Article and Find Full Text PDFBehavioral Features and Blood Enzyme Activity in Offspring of Rats Conceived from an Alcohol-Intoxicated Father.
Biochemistry (Mosc)
November 2024
Federal Research Center for Innovator and Emerging Biomedical and Pharmaceutical Technologies, P. K. Anokhin Research Institute of Normal Physiology, Moscow, 125315, Russia.
Article Synopsis
- * Results show that offspring of intoxicated fathers have significantly reduced motor activity and altered anxiety-like and depressive-like behaviors.
- * The findings suggest that alcohol consumption by males may affect gene methylation in offspring, leading to changes in enzyme activity and neuropeptide balance that influence behavior.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!