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Bleeding risk and prediction model to predict bleeding risk of tissue biopsy for definitive diagnosis in patients with suspected amyloidosis.
Ann Med
December 2025
Hematology Unit, Division of Internal Medicine, Faculty of Medicine, Prince of Songkla University, Hatyai, Songkhla, Thailand.
Introduction: Bleeding from the affected organs is a common manifestation of amyloidosis. The risk for perioperative bleeding in patients with amyloidosis remains controversial. In this study, we aimed to compare the bleeding risk of tissue biopsies for a definitive diagnosis between patients with and without amyloidosis, identify risk factors, and generate a prediction model for bleeding risk in these patients.
View Article and Find Full Text PDFPathologic responses and clinical outcomes with neoadjuvant doublet chemotherapy for newly diagnosed, surgically-resectable p16-positive oropharyngeal cancer.
Oral Oncol
January 2025
Division of Otolaryngology-Head and Neck Surgery, The George Washington University School of Medicine & Health Sciences, Washington DC, USA. Electronic address:
Background: The feasibility and outcomes of neoadjuvant doublet chemotherapy with cisplatin and docetaxel followed by surgical resection of residual disease (NAC + S) for patients with newly diagnosed, resectable p16 positive (+) oropharyngeal squamous cell carcinoma (OPSCC) has been reported from a single institution. Here, we report pathologic responses, need for adjuvant treatment and recurrence-free survival (RFS) following this treatment from a second large academic institution.
Methods: A retrospective cohort study of patients with p16 + OPSCC receiving NAC + S and risk-adjusted adjuvant treatment between January 2017 and March 2024 was performed.
Prone positioning of nonintubated patients with COVID-19 in Australian intensive care units.
Crit Care Resusc
December 2024
Australian and New Zealand Intensive Care - Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne Australia.
Objective: To describe the use of and outcomes from awake prone positioning (APP) in nonintubated patients with COVID-19 in Australian intensive care units (ICUs) in comparison to those who did not receive APP, and to explore the temporal relationship between publication of APP research and changes in clinical practice.
Design: Multicentre, observational cohort study.
Setting: Seventy-eight Australian ICUs participating in SPRINT-SARI Australia.
Comparing percutaneous coronary intervention and coronary artery bypass grafting for left main stenosis on the basis of current regional registry evidence.
JTCVS Open
December 2024
Department of Cardiothoracic Surgery, Friedrich-Schiller-University Jena, Jena, Germany.
Objectives: There is an ongoing debate whether percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) is the better choice for treatment of left main (LM) stenosis. We aimed to provide external validation for the recently reviewed guideline recommendations for invasive LM therapy by evaluating the impact of CABG or PCI on long-term survival from local reports of different regions in the world. We performed a systematic review and meta-analysis to address contemporary registry studies comparing PCI and CABG for patients with LM stenosis.
View Article and Find Full Text PDFThe literacy barrier in clinical trial consents: a retrospective analysis.
EClinicalMedicine
September 2024
Brown University, Providence, RI, USA.
Background: Historically, the readability of consent forms in medicine have been above the average reading level of patients. This can create challenges in obtaining truly informed consent, but the implications on clinical trial participant retention are not fully explored. To address this gap, we seek to analyze clinical trial consent forms by determining their readability and relationship with the associated trial's participant dropout rate.
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