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Association of Past Smoking Status With Gout in Māori People in Aotearoa New Zealand.
J Rheumatol
November 2024
L.K. Stamp, MBChB, PhD, Department of Medicine, University of Otago, Christchurch, New Zealand.
Objective: Evidence for an association of smoking with gout is conflicting. We assessed associations of current and past smoking with gout in an Aotearoa New Zealand (NZ) population.
Methods: Multivariable logistic regression analysis was performed on cross-sectional data from participants of NZ Māori (from 2 studies: Genetics of Gout in Aotearoa [GGA] study of 293 participants with gout and 431 without; and Ngāti Porou Hauora [NPH] study of 111 participants with gout and 42 without), Pacific people (257 participants with gout and 357 without), and European (694 participants with gout and 688 without) ancestry.
'Gout was like the boss'. A qualitative study exploring the impact of gout on employment.
RMD Open
August 2024
Faculty of Medical and Health Sciences, Department of Medicine, The University of Auckland, Auckland, New Zealand.
Objective: Previous research has identified that gout impacts various domains of daily life. However, there have been no qualitative studies focusing on employment. This study aimed to understand the impact of gout on employment.
View Article and Find Full Text PDFAssociation of rare and common genetic variants in MOCOS with inadequate response to allopurinol.
Rheumatology (Oxford)
November 2024
Department of Medicine, University of Otago, Christchurch, Aotearoa, New Zealand.
Objectives: The minor allele of the common rs2231142 ABCG2 variant predicts inadequate response to allopurinol urate lowering therapy. We hypothesize that additional variants in genes encoding urate transporters and allopurinol-to-oxypurinol metabolic enzymes also predict allopurinol response.
Methods: This study included a subset of participants with gout from the Long-term Allopurinol Safety Study Evaluating Outcomes in Gout Patients (LASSO), whose whole genome was sequenced (n = 563).
Easing the way to achieving target serum urate in people with gout: protocol for a non-inferiority randomised strategy trial using an allopurinol dosing model in Aotearoa/New Zealand (the Easy-Allo Study).
BMJ Open
August 2024
Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.
Introduction: Gout is one of the most common forms of arthritis worldwide. Gout is particularly prevalent in Aotearoa/New Zealand and is estimated to affect 13.1% of Māori men, 22.
View Article and Find Full Text PDFThe pathogenesis of gout: molecular insights from genetic, epigenomic and transcriptomic studies.
Nat Rev Rheumatol
August 2024
Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, USA.
Article Synopsis
- The development of gout starts with high levels of uric acid (hyperuricaemia), leading to the formation of monosodium urate crystals in joints, which trigger an immune response mediated by the NLRP3 inflammasome.
- Genome-wide association studies (GWAS) have identified various genetic factors, particularly those affecting urate transporters, along with the potential role of uncommon genetic variants and epigenomic changes affecting inflammation and immune responses.
- Research continues to expand beyond just European populations, helping to uncover different genetic variants that may be unique to other groups and furthering our understanding of gout’s molecular mechanisms.
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