AI Article Synopsis
- Air pollution in China, particularly from polycyclic aromatic hydrocarbons (PAHs), poses severe health risks, yet the full extent of exposure and its impacts remain unclear.
- A study comparing urinary concentrations of 12 hydroxylated-PAHs (Σ12OH-PAHs) and malondialdehyde (MDA) found significantly higher levels of Σ12OH-PAHs in Beijing than in Los Angeles, indicating greater exposure in Beijing.
- Results also showed a potential change in metabolism related to PAH exposure, highlighting the need for further research to understand the health implications of these alterations.
Article Abstract
Air pollution is among the top threats to human health in China. As air toxicants, polycyclic aromatic hydrocarbons (PAHs) could bring significant risks to population; however, the exposure to PAHs in China and its health impact are not fully understood. In 2012, a summer exchange program allowed 10 students to travel from Los Angeles to Beijing and stay there for 10 weeks. Based on the program, this study investigated the difference in urinary concentration of 12 hydroxylated-PAHs (Σ12OH-PAHs) and malondialdehyde (MDA) between the two cities. The median concentration of Σ12OH-PAHs in Beijing (14.1 μg g(-1) creatinine) was significantly higher than that in Los Angeles (5.78 μg g(-1) creatinine), indicating a higher exposure in Beijing. The ratios of homogeneous OH-PAHs (e.g., 1-/2-OH-NAP) changed significantly between the two cities (p < 0.01), which might suggest a potential alteration in metabolism subsequent to exposure. A significant association between Σ12OH-PAHs and MDA (p < 0.01) was observed, with the association varying between the two cities. This study suggests that exposure to PAHs might be linked to metabolism alteration and calls for future studies to investigate the role this possible alteration played in the health effects of PAHs exposure.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6057150 | PMC |
| http://dx.doi.org/10.1021/acs.est.5b04629 | DOI Listing |
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