The cerebrum of large mammals is convoluted, whereas that of small mammals is smooth. Mota and Herculano-Houzel (Reports, 3 July 2015, p. 74) inspired a model on an old theory that proposed a fractal geometry. I show that their model reduces to the product of gray-matter proportion times the folding index. This proportional relation describes the available data even better than the fractal model.
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http://dx.doi.org/10.1126/science.aad0127 | DOI Listing |
PLoS Biol
November 2024
Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, Heraklion, Greece.
Bottom-up, data-driven, large-scale models provide a mechanistic understanding of neuronal functions. A new study in PLOS Biology builds a biologically realistic model of the rodent CA1 region that aims to become an accessible tool for the whole hippocampal community.
View Article and Find Full Text PDFJ Neurol
November 2024
ENT Service, Guy's and St Thomas' NHS Foundation Trust Hospital, London, UK.
JAMA Psychiatry
December 2024
Department of Child and Adolescent Psychiatry, University Hospital Goethe University, Frankfurt am Main, Germany.
Importance: In the neurotypical brain, regions develop in coordinated patterns, providing a fundamental scaffold for brain function and behavior. Whether altered patterns contribute to clinical profiles in neurodevelopmental conditions, including autism, remains unclear.
Objectives: To examine if, in autism, brain regions develop differently in relation to each other and how these differences are associated with molecular/genomic mechanisms and symptomatology.
N Engl J Med
October 2024
IRCCS Istituto Giannina Gaslini, Genoa, Italy
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