A 5-year Integrated Vector Management (IVM) project was implemented in Pondicherry, South India, for the control of Bancroftian filariasis. The efficacy of the IVM strategy was compared with routine control strategy under the national programme. The present paper describes the pre-control epidemiological features of filariasis as determined by a mass blood survey in 1981. Of 24946 persons examined 8.41% were microfilaraemic. Microfilaraemia prevalence was homogeneous throughout the study area. The prevalence and intensity of microfilaraemia were age dependent, and increased monotonically until about 20 years, following which there was a decline until about 40 years to become relatively stable in older age classes. The gender profiles of both prevalence and intensity of microfilaraemia showed no difference between the sexes until about 15 years of age, following which both were higher in males compared to females. The distribution of microfilarial counts was overdispersed, indicating aggregation of adult worms.
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http://dx.doi.org/10.1017/s0950268800031083 | DOI Listing |
PLoS One
January 2025
Centre for Clinical Research, The University of Queensland, Brisbane, QLD, Australia.
Background: Lymphatic filariasis (LF), a mosquito-borne parasitic disease caused by three species of filarial worms, was first detected in Niue, a small Pacific Island nation of approximately 1,600 people, in 1954. After extensive efforts involving multiple rounds of Mass Drug Administration, Niue was validated by the World Health Organization (WHO) as having e4liminated LF as a public health problem in 2016. However, no surveillance has been conducted since validation to confirm infection rates have remained below WHO's elimination threshold.
View Article and Find Full Text PDFPLoS Negl Trop Dis
January 2025
International Lymphoedema Framework, London, United Kingdom.
Background: The World Health Organization launched the Global Programme to Eliminate Lymphatic Filariasis in 2000, which aimed at eradicating the disease by 2030. This goal depends on community mass drug administration and essential care. Despite these efforts, many rural communities still face untreated lymphatic filariasis and lack access to treatment and self-management.
View Article and Find Full Text PDFPLoS Negl Trop Dis
January 2025
NLR | until No Leprosy Remains, Amsterdam, The Netherlands.
Background: People with disabilities due to neglected tropical diseases (NTDs), such as leprosy and lymphatic filariasis (LF), often encounter situations of stigma and discrimination that significantly impact their mental wellbeing. Mental wellbeing services are often not available at the peripheral level in NTD-endemic countries, and there is a need for such services. Basic psychological support for persons with NTDs (BPS-N) from peers is an important potential solution for addressing mental wellbeing problems.
View Article and Find Full Text PDFParasit Vectors
January 2025
National Centre for Epidemiology and Population Health, Australian National University, 62 Mills Road, Canberra, 2601, ACT, Australia.
Background: Elimination of lymphatic filariasis (LF) is a World Health Organization goal, with several countries at or near prevalence thresholds. Where LF cases remain after mass drug administration, they tend to be spatially clustered, with an overdispersed individual worm burden. Both individual and spatial heterogeneities can cause aggregation of infection; however, few studies have investigated the drivers of heterogeneity and implications for disease elimination.
View Article and Find Full Text PDFPathogens
December 2024
School of Artificial Intelligence, Hangzhou Dianzi University, Hangzhou 310018, China.
is a parasite transmitted by mosquitoes and can cause a neglected tropical disease called Lymphatic filariasis. However, the genome of was not well studied, making novel drug development difficult. This study aims to identify microRNA, annotate protein function, and explore the pathogenic mechanism of by genome-wide analysis.
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