Selective, non-covalent conjugation of synthetic peptides with recombinant proteins mediated by host-guest chemistry.

Chem Commun (Camb)

Formulation Sciences, MedImmune Ltd, Granta Park, Cambridge CB21 6GH, UK.

Published: March 2016

The combination of potent chemical moieties with biologically active proteins is key to some of today's most innovative therapeutic drugs. In order to obviate any chemical modification of the proteins, we present a novel and powerful strategy for the selective conjugation of recombinant protein domains with synthetically derived peptides via a cucurbit[8]uril host-guest chemistry approach.

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Source
http://dx.doi.org/10.1039/c6cc00405aDOI Listing

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