AI Article Synopsis
- Researchers developed new analogues of the natural compound pycnanthulignene D using a streamlined synthesis process.
- The starting materials, plant allylalkoxybenzenes, are readily sourced from essential oils of sassafras, dill, and parsley.
- The synthesized compounds showed potential antiproliferative effects in a sea urchin embryo assay, indicating possible applications in biomedical research.
Article Abstract
Analogues of the bioactive natural alkoxynaphthalene pycnanthulignene D were synthesized by an efficient method. The starting plant allylalkoxybenzenes (1) are easily available from the plant essential oils of sassafras, dill, and parsley. The target 1-arylalkoxynaphthalenes (5) exhibited antiproliferative activity in a phenotypic sea urchin embryo assay.
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| http://dx.doi.org/10.1021/acs.jnatprod.5b01007 | DOI Listing |
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