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| http://dx.doi.org/10.1056/NEJMp1600893 | DOI Listing |
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View Article and Find Full Text PDFThe proneural transcription factor Atoh1 promotes odontogenic differentiation in human dental pulp stem cells (DPSCs).
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Leber's hereditary optic neuropathy (LHON) is an ocular mitochondrial disease that involves the impairment of mitochondrial complex I, which is an important contributor to blindness among young adults across the globe. However, the disorder has no available cures, since the approved drug idebenone for LHON in Europe relies on bypassing complex I defects rather than fixing them. Herein, mRNA-loaded nanoparticle (mNP)-engineered mitochondria (mNP-Mito) were designed to replace dysfunctional mitochondria with the delivery of exogenous mitochondria, normalizing the function of complex I for treating LHON.
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