Objective: In order to elucidate the interrelationship of adipokines in glucose hemiostasis, we determined the concentration of visfatin and adipsin in blood samples in patients with type 2 diabetes and age-matched controls after an overnight fast.
Subjects And Methods: We enrolled 37 patients with known type 2 diabetes -21 males and 16 females, aged 62.95 ± 15.72 years and 43 controls- 28 males and 15 females, aged 60.79 ± 12.67 years. Blood samples were collected after an overnight fast and routine biochemical parameters such as glucose, cholesterol, HDL, LDL, triglycerides along with Hb1Ac, insulin and c-peptide, in addition to circulating visfatin and adipsin were determined in all samples. Data were considered significant at a level of p < 0.05.
Results: In patients with type 2 diabetes, circulating adipsin levels were decreased and inversely related with glucose levels while circulating visfatin was increased significantly in the fasting state.
Conclusion: These results implicate the adipokines adipsin and visfatin as possible participants in the pathogenesis of type 2 diabetes.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10118915 | PMC |
| http://dx.doi.org/10.1590/2359-3997000000147 | DOI Listing |
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