AI Article Synopsis
- Basic experimental stem cell research has potential clinical applications, but only a few diseases have progressed to clinical trials.
- Pluripotent stem cell derivatives could offer a scalable source of functional cells for repairing various tissues, promising treatment options for a wide range of conditions.
- To ensure the safety of these treatments, extensive data collection and a lengthy regulatory process are required before they can be widely available.
Article Abstract
Basic experimental stem cell research has opened up the possibility of many diverse clinical applications; however, translation to clinical trials has been restricted to only a few diseases. To broaden this clinical scope, pluripotent stem cell derivatives provide a uniquely scalable source of functional differentiated cells that can potentially repair damaged or diseased tissues to treat a wide spectrum of diseases and injuries. However, gathering sound data on their distribution, longevity, function and mechanisms of action in host tissues is imperative to realizing their clinical benefit. The large-scale availability of treatments involving pluripotent stem cells remains some years away, because of the long and demanding regulatory pathway that is needed to ensure their safety.
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| http://dx.doi.org/10.1038/nrm.2016.10 | DOI Listing |
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