AI Article Synopsis
- High-carbohydrate diets can lead to obesity and metabolic disorders such as hypertriglyceridemia (HTG), increasing risks for cardiovascular disease and type 2 diabetes.
- This study investigates the association of the TAS1R2 gene polymorphism (Ile191Val) with carbohydrate intake and HTG among 441 subjects in West Mexico.
- Findings reveal that those with the Val/Val genotype consume more carbohydrates and have a significantly higher risk for HTG, along with approximately 30% higher triglyceride levels compared to other genotypes.
Article Abstract
Some high-carbohydrate diets may lead to obesity and multiple metabolic disorders, including hypertriglyceridemia (HTG). This lipid abnormality is considered an important risk factor for cardiovascular disease and type 2 diabetes. The sweet taste receptor TAS1R2 polymorphism (Ile191Val) has been reported to be associated with carbohydrate intake. The aim of this study was to analyze the association of the TAS1R2 gene polymorphism with carbohydrate intake and HTG among the population of West Mexico. In a cross-sectional study, 441 unrelated subjects were analyzed for TAS1R2 genotypes (Ile/Ile, Ile/Val and Val/Val) by an allelic discrimination assay. Biochemical tests and a three-day food record were assessed. The Val/Val genotype carriers had a higher intake of total carbohydrates, fiber and servings of cereals and vegetables than the other genotype carriers. The Val/Val genotype conferred a higher risk for HTG than the Ile/Val and Ile/Ile genotypes (OR = 3.26, 95%CI 1.35-7.86, p = 0.006 and OR = 2.61, 95%CI 1.12-6.07, p = 0.02, respectively). Furthermore, the Val/Val genotype was associated with approximately 30% higher triglycerides compared with Ile/Val and Ile/Ile genotypes (β = 44.09, 95%CI 9.94-78.25, p = 0.01 and β = 45.7, 95%CI 10.85-80.54, p = 0.01, respectively). In conclusion, the Val/Val genotype of TAS1R2 was associated with a higher carbohydrate intake and HTG.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4772063 | PMC |
| http://dx.doi.org/10.3390/nu8020101 | DOI Listing |
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