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Dual physiological responsive structural color hydrogel particles for wound repair.
Bioact Mater
April 2025
Joint Centre of Translational Medicine, Wenzhou Key Laboratory of Interdiscipline and Translational Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Hydrogel-based patches have demonstrated their values in diabetic wounds repair, particularly those intelligent dressings with continuous repair promoting and monitoring capabilities. Here, we propose a type of dual physiological responsive structural color particles for wound repair. The particles are composed of a hyaluronic acid methacryloyl (HAMA)-sodium alginate (Alg) inverse opal scaffold, filled with oxidized dextran (ODex)/quaternized chitosan (QCS) hydrogel.
View Article and Find Full Text PDFA novel machine learning based framework for developing composite digital biomarkers of disease progression.
Front Digit Health
January 2025
Biostatistics and Research Decision Sciences, Merck & Co., Inc., Rahway, NJ, United States.
Background: Current methods of measuring disease progression of neurodegenerative disorders, including Parkinson's disease (PD), largely rely on composite clinical rating scales, which are prone to subjective biases and lack the sensitivity to detect progression signals in a timely manner. Digital health technology (DHT)-derived measures offer potential solutions to provide objective, precise, and sensitive measures that address these limitations. However, the complexity of DHT datasets and the potential to derive numerous digital features that were not previously possible to measure pose challenges, including in selection of the most important digital features and construction of composite digital biomarkers.
View Article and Find Full Text PDFMusicians and researchers: two creative professions striving to improve heart health through music.
Front Cardiovasc Med
January 2025
Institute of Molecular Pathobiochemistry, Experimental Gene Therapy and Clinical Chemistry (IFMPEGKC), RWTH University Hospital Aachen, Aachen, Germany.
Musicians and researchers are creative professions that share many similarities. They both aim to bring joy and progress to humanity. In recent decades, it has been shown that music has the ability to alleviate pain, improve heart function, reduce anxiety, and stimulate the release of endogenous opioids in the brain.
View Article and Find Full Text PDFYale-Brown Obsessive-Compulsive Scale Modified for Body Dysmorphic Disorder: Factor Structure and Construct Validity of Subfactors.
J Obsessive Compuls Relat Disord
July 2024
Department of Psychiatry, Massachusetts General Hospital/Harvard Medical School.
The Yale-Brown Obsessive-Compulsive Scale modified for Body Dysmorphic Disorder (BDD-YBOCS) is a semi-structured interview designed to assess the severity of current BDD. The aim of the study was to examine the factor structure and construct validity of the BDD-YBOCS. The sample included 366 adults with BDD who completed the BDD-YBOCS and other measures of BDD severity/impairment, psychiatric distress (i.
View Article and Find Full Text PDFGuidance on the planning and reporting of experimental design and analysis.
Br J Pharmacol
January 2025
Department of Pharmacology and Pharmacotherapy, Semmelweis University, Budapest, Hungary.
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