AI Article Synopsis
- Visual motion is processed through separate On and Off pathways in the retina that connect to specific starburst amacrine cells (SACs).
- Researchers reconstructed and classified different types of On bipolar cells (BCs) using electron microscopy and identified a new type.
- The study found that the wiring of On BCs to On SACs is structured similarly to the wiring of Off BCs to Off SACs, supporting the idea that both pathways use similar mechanisms for detecting motion.
Article Abstract
Visual motion information is computed by parallel On and Off pathways in the retina, which lead to On and Off types of starburst amacrine cells (SACs). The approximate mirror symmetry between this pair of cell types suggests that On and Off pathways might compute motion using analogous mechanisms. To test this idea, we reconstructed On SACs and On bipolar cells (BCs) from serial electron microscopic images of a mouse retina. We defined a new On BC type in the course of classifying On BCs. Through quantitative contact analysis, we found evidence that sustained and transient On BC types are wired to On SAC dendrites at different distances from the SAC soma, mirroring our previous wiring diagram for the Off BC-SAC circuit. Our finding is consistent with the hypothesis that On and Off pathways contain parallel correlation-type motion detectors.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6404534 | PMC |
| http://dx.doi.org/10.1016/j.celrep.2016.02.001 | DOI Listing |
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