AI Article Synopsis
- - This study aimed to understand how the order of administering Hepatitis B and DTwP vaccines affects pain responses in infants.
- - Conducted at LLRM Medical College, the randomized trial involved 130 healthy infants under 4 months, comparing pain levels based on whether they received the DTwP or Hepatitis B first.
- - Results indicated that infants experienced less pain (and showed better heart rate and oxygen saturation) when receiving the Hepatitis B vaccine before the DTwP vaccine.
Article Abstract
Objective: This study was designed with objective to study pain response of infants to change in sequence of administration of Hepatitis B and DTwP vaccines.
Methods: This was a randomized parallel control trial. The study was carried out in the immunization clinic of the Department of Pediatrics, LLRM Medical College, Meerut. One hundred and thirty healthy term infants up to 4 months of age were injected either DTwP vaccine first or Hepatitis B vaccine first, followed one minute later by the other vaccine.
Result: Baseline characteristics did not differ between the groups. The mean (SD) of AUC of MFCS and NIPS was significantly more in DF group as compared to HF group (for MFCS 25.5 ± 5.4 versus 22.5 ± 5.5, p<0.01; for NIPS 31.77 ± 5.5 versus 27.64 ± 6.9, p < 0.01). Similarly mean (SD) of AUC of Heart rate and saturation of oxygen showed significant variation in DF group as compared to HF group (for heart rate 591.6 ± 55 versus 559.6 ± 49, p< 0.01; for SpO2 326.4 ± 12 versus 335 ± 8, p < 0.01).
Conclusion: These results showed that infant experienced lesser pain when Hepatitis B was administered first than when DTwP vaccine was given first.
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Source |
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| http://dx.doi.org/10.1016/j.vaccine.2016.02.031 | DOI Listing |
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