A brief survey of the literature on gamma-glutamyl transpeptidase (gamma-GT) activity is included in this study. The levels of activity in the serum of normal Merino sheep (13,6-32,4 mI.U/ml) were ascertained as a preliminary to following the activity through the entire course of experimentally induced ovine lupinosis, a hepatotoxicosis caused by Phomopsis leptostromiformis (Kühn) Bubák. The response of the serum level of gamma-GT activity to the course of the disease was compared with that of glutamate oxaloacetic transaminase (GOT) and 2 liver function tests for the purpose of assessing its potential application in the study of this mycotoxicosis. Because the levels of activity of gamma-GT were more valuable for the early diagnosis of low grade acute intoxication and the detection of chronic liver involvement while those of GOT gave better information on the development of severe acute hepato-cellular damage, these 2 enzymes, considered together, were found to give the best information on the course of the toxicosis. The changes in gamma-GT activity during various stages of intoxication were also related to the histopathological lesions in the liver.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Pancreatic cancer cell-intrinsic transglutaminase-2 promotes T cell suppression through microtubule-dependent secretion of immunosuppressive cytokines.
J Immunother Cancer
January 2025
Internal Medicine I, Ulm University Hospital, Ulm, Germany
Background: Pancreatic ductal adenocarcinoma (PDAC) is mostly refractory to immunotherapy due to immunosuppression in the tumor microenvironment and cancer cell-intrinsic T cell tolerance mechanisms. PDAC is described as a "cold" tumor type with poor infiltration by T cells and factors leading to intratumoral T cell suppression have thus received less attention. Here, we identify a cancer cell-intrinsic mechanism that contributes to a T cell-resistant phenotype and describes potential combinatorial therapy.
View Article and Find Full Text PDFModerately mechanically activated starch in improving protein digestibility: Application in noodles.
Int J Biol Macromol
January 2025
College of Food Science and Engineering, Henan University of Technology, Zhengzhou, Henan Province, PR China. Electronic address:
The aim of this study was to investigate the mechanism of protein digestibility improvement by exploring the changes in structural characteristics of proteins in noodles with varying levels of mechanically activated starch. Therefore, different levels of mechanically activated wheat starch were mixed with refined wheat flour to produce noodles. Results showed that moderately mechanically activated starch could significantly improve protein digestibility and noodles containing 8.
View Article and Find Full Text PDFAlpinetin Exhibits Antioxidant and Anti-Inflammatory Effects in C57BL/6 Mice with Alcoholic Liver Disease Induced by the Lieber-DeCarli Ethanol Liquid Diet.
Int J Mol Sci
December 2024
Department of Physiology, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, Serbia.
Alcohol-associated liver disease (ALD) is a common non-communicable chronic liver disease characterized by a spectrum of conditions ranging from steatosis and alcohol-associated steatohepatitis (AH) to fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). The pathogenesis of ALD involves a complex interplay of various molecular, biochemical, genetic, epigenetic, and environmental factors. While the mechanisms are well studied, therapeutic options remain limited.
View Article and Find Full Text PDFDetermination of Westcott g-factors for the assay of non-1/v nuclides using k-NAA.
Appl Radiat Isot
January 2025
Reactor Design Group, IGCAR, Kalpakkam, 603102, India.
This study examines the impact of the Westcott g-factor on the concentration of elements like In, Ir, Re, Yb, Eu and Lu, measured using neutron capture reactions (n,γ), specifically focusing on those reactions, whose thermal neutron capture cross-sections (σ ) deviate from the conventional '1/v' behaviour. These measurements are quantified using k₀-based neutron activation analysis. The Westcott g-factor for the non-1/v nuclides was calculated using the characterized neutron temperature (T) at PFTS irradiation channel of KAMINI reactor.
View Article and Find Full Text PDFThe Search for a Universal Treatment for Defined and Mixed Pathology Neurodegenerative Diseases.
Int J Mol Sci
December 2024
Department of Biology, University of Toronto Mississauga, Mississauga, ON L5L 1C6, Canada.
The predominant neurodegenerative diseases, Alzheimer's disease, Parkinson's disease, dementia with Lewy Bodies, Huntington's disease, amyotrophic lateral sclerosis, and frontotemporal dementia, are rarely pure diseases but, instead, show a diversity of mixed pathologies. At some level, all of them share a combination of one or more different toxic biomarker proteins: amyloid beta (Aβ), phosphorylated Tau (pTau), alpha-synuclein (αSyn), mutant huntingtin (mHtt), fused in sarcoma, superoxide dismutase 1, and TAR DNA-binding protein 43. These toxic proteins share some common attributes, making them potentially universal and simultaneous targets for therapeutic intervention.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!