Context: Available markers are not reliable parameters to early detect kidney injury in transplanted patients.
Objective: Examine neutrophil gelatinase associated lipocalin (NGAL) in early detection of delayed graft function (DGF) and as a long-term predictor of graft outcome.
Patients And Methods: NGAL was evaluated in 124 transplanted patients.
Results: Urinary NGAL levels were associated to a 10% (HR: 1.10; 95% CI: 1.04-1.25; p < 0.001) and 15% (HR: 1.15; 95% CI: 1.09-1.26; p < 0.001) increased risk of DGF and allograft nephropathy progression, respectively.
Conclusion: NGAL reflects the entity of renal impairment in transplanted patients, representing a biomarker and an independent risk factor for DGF and chronic allograft nephropathy progression.
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| http://dx.doi.org/10.3109/1354750X.2016.1141991 | DOI Listing |
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