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Glia-like taste cells mediate an intercellular mode of peripheral sweet adaptation.
Cell
January 2025
School of Biological Sciences, Seoul National University, Seoul 08826, Republic of Korea; The Institute of Molecular Biology and Genetics, Seoul 08826, Republic of Korea. Electronic address:
The sense of taste generally shows diminishing sensitivity to prolonged sweet stimuli, referred to as sweet adaptation. Yet, its mechanistic landscape remains incomplete. Here, we report that glia-like type I cells provide a distinct mode of sweet adaptation via intercellular crosstalk with chemosensory type II cells.
View Article and Find Full Text PDFDistorted neurocomputation by a small number of extra-large spines in psychiatric disorders.
Sci Adv
June 2023
Laboratory for Multi-scale Biological Psychiatry, Center for Brain Science, RIKEN, 2-1 Hirosawa, Wako City, Saitama 351-0106, Japan.
Human genetics strongly support the involvement of synaptopathy in psychiatric disorders. However, trans-scale causality linking synapse pathology to behavioral changes is lacking. To address this question, we examined the effects of synaptic inputs on dendrites, cells, and behaviors of mice with knockdown of SETD1A and DISC1, which are validated animal models of schizophrenia.
View Article and Find Full Text PDFTargeting the post-synaptic proteome has therapeutic potential for psychosis in Alzheimer Disease.
Commun Biol
June 2023
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Individuals with Alzheimer Disease who develop psychotic symptoms (AD + P) experience more rapid cognitive decline and have reduced indices of synaptic integrity relative to those without psychosis (AD-P). We sought to determine whether the postsynaptic density (PSD) proteome is altered in AD + P relative to AD-P, analyzing PSDs from dorsolateral prefrontal cortex of AD + P, AD-P, and a reference group of cognitively normal elderly subjects. The PSD proteome of AD + P showed a global shift towards lower levels of all proteins relative to AD-P, enriched for kinases, proteins regulating Rho GTPases, and other regulators of the actin cytoskeleton.
View Article and Find Full Text PDFVesicular Glutamate Transporter Changes in the Cortical Default Mode Network During the Clinical and Pathological Progression of Alzheimer's Disease.
J Alzheimers Dis
July 2023
Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Background: Altered glutamatergic neurotransmission may contribute to impaired default mode network (DMN) function in Alzheimer's disease (AD). Among the DMN hub regions, frontal cortex (FC) was suggested to undergo a glutamatergic plasticity response in prodromal AD, while the status of glutamatergic synapses in the precuneus (PreC) during clinical-neuropathological AD progression is not known.
Objective: To quantify vesicular glutamate transporter VGluT1- and VGluT2-containing synaptic terminals in PreC and FC across clinical stages of AD.
Experience-dependent plasticity of gustatory insular cortex circuits and taste preferences.
Sci Adv
January 2023
Department of Neurobiology and Behavior, SUNY Stony Brook, Stony Brook, NY, USA.
Early experience with food influences taste preference in adulthood. How gustatory experience influences development of taste preferences and refinement of cortical circuits has not been investigated. Here, we exposed weanling mice to an array of taste solutions and determined the effects on the preference for sweet in adulthood.
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