The relationship of anxiety to depression in children and adolescents has perplexed and preoccupied researchers and professionals in the field of child and adolescent psychiatry over the last two decades. This article illustrates this as it is demonstrated through epidemiologic, genetic, and biologic issues as well as environmental and developmental considerations and investigated procedures. The relevant literature is reviewed in depth, and the discussion on the inter-relatedness of the various factors, as they influence anxiety and depression, is brought forth.
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