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Statistical tools and control of internal lubricant content of inhalation grade HPMC capsules during manufacture. | LitMetric

Statistical tools and control of internal lubricant content of inhalation grade HPMC capsules during manufacture.

Int J Pharm

Qualicaps Europe, S.A.U., Avda. de Valdelatas 4, 28108 Alcobendas, Madrid, Spain. Electronic address:

Published: April 2016

AI Article Synopsis

Article Abstract

The internal lubricant content (ILC) of inhalation grade HPMC capsules is a key factor to ensure good powder release when the patient inhales a medicine from a dry powder inhaler (DPI). Powder release from capsules has been shown to be influenced by the ILC. The characteristics used to measure this are the emitted dose, fine particle fraction and mass median aerodynamic diameter. In addition the ILC level is critical for capsule shell manufacture because it is an essential part of the process that cannot work without it. An experiment has been applied to the manufacture of inhalation capsules with the required ILC. A full factorial model was used to identify the controlling factors and from this a linear model has been proposed to improve control of the process.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijpharm.2016.02.017DOI Listing

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