Catalytic selective deuteration of halo(hetero)arenes.

Org Biomol Chem

School of Chemical Sciences, National Institute of Science Education and Research (NISER), Bhimpur-Padanpur (PO), Jatni (via), Khurda - 752050, Odisha, India.

Published: March 2016

Deuterium labeled aromatic and heteroaromatic compounds are synthesized in good to excellent yields with >98% deuterium purity via palladium catalyzed deuterodehalogenation reaction using commercially available and inexpensive reagents. Selective deuteration of bromoaniline is also demonstrated without H/D exchange in an amino N-H group.

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Source
http://dx.doi.org/10.1039/c6ob00193aDOI Listing

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