Background: Arterial hypertension is associated with a high prevalence of vascular alterations. The use of noninvasive procedures to assess peripheral arterial diseases in the ranking of cardiovascular risks has been increasingly valued in clinical practice and should be adopted in nursing.
Objective: To identify the cardiovascular risk of hypertensive and normotensive individuals through the use of different noninvasive procedures to assess the vascular function and integrity: ankle-brachial index, pulse pressure, and delta brachial-brachial and delta ankle-brachial indexes.
Methods: Quantitative, descriptive, and cross-sectional study undertaken at a health service in a Brazilian city. The research variables were age, sex, blood pressure, abdominal circumference, body mass index, ankle-brachial index, pulse pressure, and delta brachial-brachial and delta ankle-brachial indexes.
Results: Fifty-four (43.1%) normotensive and 69 (56.9%) hypertensive individuals participated in the study. Alterations were identified in ankle-brachial index, corresponding to mild and moderate arterial obstruction, among hypertensive individuals only (7.2%), with higher pulse pressure indices (P < 0.0001). The assessment of the correlation between the ankle-brachial index and pulse pressure showed no correlation in the normotensive group and a statistically significant correlation among hypertensive patients (Pearson's coefficient = -0.45, P < 0.0001, r(2) = 0.21). A statistically significant difference (P < 0.05) was found in the analysis of the mean delta brachial-brachial (6.2 ± 0.71 mm Hg for normotensive and 10.16 ± 1.45 mm Hg for hypertensive individuals) and delta ankle-brachial index (0.06 ± 0.01 for normotensive and 0.11 ± 0.01 for hypertensive individuals).
Conclusions: The use of the proposed cardiovascular risk predictors shows more frequent alterations among hypertensive than normotensive individuals.
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http://dx.doi.org/10.1016/j.jvn.2015.10.001 | DOI Listing |
Afr J Reprod Health
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Hangzhou Institute of Technology, Xidian University, Hangzhou 311200, China.
A highly sensitive sulfur dioxide (SO) photoacoustic gas sensor was developed for the sulfur hexafluoride (SF) decomposition detection in electric power systems by using a novel 266 nm low-cost high-power solid-state pulse laser and a high -factor differential photoacoustic cell. The ultraviolet (UV) pulse laser is based on a passive -switching technology with a high output power of 28 mW. The photoacoustic signal was normalized to the laser power to solve the fluctuation of the photoacoustic signal due to the power instability of the UV laser.
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Department of Pharmaceutics, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Alkharj 11942, Saudi Arabia.
Angiotensin-converting enzyme (ACE) is a key regulator of blood pressure, and ACE inhibition is an essential part of the treatment of hypertension. We used a molecular docking approach to find the interaction of ACE with an active flavonoid isolated from Linn, , which leads to potential antihypertensive effects in methyl predenisolone-induced hypertensive rats. Additionally, the pharmacokinetic parameters of this compound are assessed.
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College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
Cyclovirobuxine D, a natural compound derived from the medicinal plant Buxus sinica, demonstrates a diverse array of therapeutic benefits, encompassing anti-arrhythmic properties, blood pressure regulation, neuronal protection, and anti-ischemic activity. However, its limited solubility hinders the bioavailability of current oral and injectable formulations, causing considerable adverse reactions and toxicity. In this investigation, we embarked on an unprecedented exploration of the skin penetration potential of cyclovirobuxine D utilizing chemical penetration enhancers and niosomes as innovative strategies to enhance its dermal absorption.
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December 2024
School of Biomedical Engineering and Imaging, Xianning Medical College, Hubei University of Science and Technology, Xianning 437100, China.
Powder-based hemostatic materials have offered unprecedented opportunities for the effective sealing and repair of irregularly shaped wounds and high-pressure, noncompressible arterial bleeding wounds caused by surgeries, traffic accidents, and wartime injuries. However, inadequate adhesion to bleeding wounds and poor hemostasis in biological tissues remains challenging. Herein, we report a self-gelling hemostatic powder based on polyacrylic acid/polyethyleneimine/polyethylene glycol (named PPG) for rapid hemostasis and effective antibacterial ability.
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