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The 40S ribosomal subunit recycling complex modulates mitochondrial dynamics and endoplasmic reticulum - mitochondria tethering at mitochondrial fission/fusion hotspots.
Nat Commun
January 2025
Department of Biological Sciences, Dedman College of Humanities and Sciences, Southern Methodist University, Dallas, TX, 75275, USA.
The 40S ribosomal subunit recycling pathway is an integral link in the cellular quality control network, occurring after translational errors have been corrected by the ribosome-associated quality control (RQC) machinery. Despite our understanding of its role, the impact of translation quality control on cellular metabolism remains poorly understood. Here, we reveal a conserved role of the 40S ribosomal subunit recycling (USP10-G3BP1) complex in regulating mitochondrial dynamics and function.
View Article and Find Full Text PDFOrganisational Inequalities and the Myth of Meritocracy: How They Impede Employee Task Performance?
Int J Psychol
February 2025
Department of Management Information Systems, College of Business Administration, Prince Sattam Bin Abdulaziz University, Al-Kharj, Saudi Arabia.
Previous studies have overlooked organisational inequalities and their influence on employee task performance. Anchored in equity theory, we address this gap by examining how promotion and compensation inequalities relate to employee task performance. Further, this study examines the myth of meritocracy as an underlying mechanism and overall perceived distributive justice as a boundary condition.
View Article and Find Full Text PDFSynthesis and evaluation of the antifungal and antibiofilm potential of aminochalcones.
Arch Microbiol
January 2025
Department of Chemistryand Environmental Sciences, Institute of Biosciences, Humanities and Exact Sciences, São Paulo State University Júlio de Mesquita Filho, São José do Rio Preto, SP, Brazil.
Candida is a commensal fungus of clinical interest that commonly lives in oral cavity and intestine but can become an opportunist microrganism and cause severe infections. A serie of 10 aminochalcones were designed and synthetized to obtain compounds anti-Candida with potent and broad-spectrum activity. The most active compound J34 demonstrated excellent in vitro activity against Candida albicans, Candida tropicalis, Candida parapsilosis, Candida glabrata and Candida krusei with minimum inhibitory concentration between 1.
View Article and Find Full Text PDFThis article examines responses from Lutheran pastors, theologians, and physicians to the arguments given by Johann Weyer in 1563 that those women who confessed to a pact with the devil suffered from melancholy and were thus not responsible for their acts. Weyer's conception of melancholy was a medical one, yet among Lutheran pastors and theologians the concept of a spiritual form of melancholy emerged that came from religious sources. The article clarifies the difference between the concepts of medical and spiritual melancholy within Lutheranism and reviews the respective roles they played in the debates over Weyer's arguments.
View Article and Find Full Text PDFThis paper examines the geopolitical implications of knowledge production in psychology through two studies that respond to the growing body of work on the 'Decolonisation of Knowledge' and the 'Decolonisation of Psychology' over the past two decades. By adopting a constructivist approach, particularly through the lens of Social Representation Theory (SRT), these studies explore the ways in which geopolitical contexts shape decolonial activism within psychological and scientific discourse. The first study sheds light on the lexical divergences in the construction of knowledge within the domains of psychology.
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