This observational cohort study assessed the effect of the introduction of antibiotic-impregnated external ventricular drains (AI-EVDs), as opposed to plain silicone EVDs, on the occurrence of ventriculostomy-related infections (VRIs) in two Dutch hospitals, with no other changes to their clinical practice. VRI was defined using the criteria of the Centers for Disease Control and Prevention, and with a culture-based definition. A propensity-score-adjusted competing risks survival analysis showed that introduction of AI-EVDs did not significantly decrease the risk of VRIs in routine care, nor affect the bacterial aetiology, even after adjustment for confounding and competing events.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.jhin.2015.12.018 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The VEntriculostomy-Related Infection Score: An Antibiotic Stewardship Tool in Ventriculostomy-Related Infections.
Neurosurgery
December 2024
Department of Anesthesia, Burn and Critical Care, University Hospitals Saint-Louis - Lariboisière, Assistance Publique-Hôpitaux de Paris (APHP), Paris, France.
Background And Objectives: Diagnosing ventriculostomy-related infection (VRI), a common complication after external ventricular drainage (EVD), is challenging and often associated with delayed initiation of antibiotic therapy. We aimed to develop a stewardship score to help in the decision of antibiotic therapy initiation when VRI is suspected.
Methods: This retrospective, single-center cohort study included patients admitted to the intensive care unit after EVD placement who were suspected of having healthcare-associated ventriculitis and/or meningitis between January 1, 2012, and August 31, 2022.
Pathophysiology and Prevention of Ventriculostomy-Related Infections: A Review.
Neurosurgery
September 2024
Department of Anaesthesiology and Critical Care, Georges Pompidou European Hospital, Paris, France.
This qualitative review aims to summarize current knowledge on ventriculostomy-related infection (VRI) pathophysiology and its prevention. VRI generally occurs at day 10, mainly because of Gram-positive cocci, after a cerebrospinal fluid leak. Skin microbiota and biofilm seem to play a major role in VRI pathogenesis.
View Article and Find Full Text PDFCorrigendum to "Heparin-bindning protein as a marker of ventriculostomy related infection and central nervous system inflammation in neuro-intensive care" [Clin. Neurol. Neurosurg. 229 (2023) 107752].
Clin Neurol Neurosurg
September 2024
Department of Medical Sciences Uppsala, Section of Infectious Diseases, Uppsala University, Uppsala, Sweden.
The incidence of ventriculostomy-related infections as diagnosed by 16S rRNA polymerase chain reaction: A prospective observational study.
J Clin Neurosci
August 2024
Northern Clinical School, Faculty of Health and Medicine, University of Sydney, Australia; Malcolm Fisher Department of Intensive Care Medicine, Royal North Shore Hospital, Sydney, Australia; Division of Critical Care, The George Institute for Global Health, Faculty of Medicine, UNSW Sydney, Australia.
Background: Ventriculostomy-related infections (VRIs) are reported in about 10 % of patients with external ventricular drains (EVDs). VRIs are difficult to diagnose due to clinical and laboratory abnormalities caused by the primary neurological injury which led to insertion of the EVD. Polymerase chain reaction (PCR) of the cerebrospinal fluid (CSF) may enable more accurate diagnosis of VRI.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!