Importance: Pelvic floor disorders (PFDs) comprise a broad spectrum of clinical conditions, including urinary incontinence, pelvic organ prolapse, fecal incontinence, and defecatory dysfunction. These disorders are common conditions that generate significant medical, emotional, social, and economic issues for many women. Obese women are disproportionately affected compared with their normal-weight peers, with more than half of women with a body mass index of greater than 35 kg/m(2) reporting a PFD, compared with only 32% in women with a normal body mass index. Despite this prevalence, little research is available to help guide and tailor treatment in obese populations.
Objective: This review outlines current knowledge regarding the relative contribution of obesity to PFDs, as well as its effect on treatment implications.
Evidence Acquisition: Literature relating to the incidence and treatment of PFDs in obese populations was reviewed.
Results: Both nonsurgical and surgical weight loss improves all PFDs. Obese women benefit from pelvic floor training, biofeedback, and pharmacologic treatments of urinary and fecal incontinence. Surgical treatments of stress urinary incontinence note increased operative times and perhaps slightly lower cure rates, but overall good treatment success in obese women. No increased risks of complications or treatment failure were noted in obese women treated for prolapse surgically, and pessaries work well for both prolapse and stress urinary incontinence in obese women.
Conclusions/relevance: Although literature regarding treatment of PFDs in obese women is limited, the available evidence demonstrates good treatment outcomes in obese populations. Further research into how to best counsel and optimize treatment of obese patients is essential as the obesity epidemic continues.
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http://dx.doi.org/10.1097/OGX.0000000000000274 | DOI Listing |
PLoS One
March 2025
Department of Ophthalmology, Hallym University School of Medicine, Dongtan Sacred Heart Hospital, Hwaseong, Republic of Korea.
This study investigates whether ocular motor cranial neuropathy (OMCN) can predict the onset of thyroid cancer given its association with common cardiovascular risk factors including obesity, diabetes mellitus (DM), hypertension, and dyslipidemia. We conducted a retrospective, nationwide, population-based cohort study utilizing data from the Korean National Health Insurance Service. Individuals comprised those aged ≥ 20 years diagnosed with OMCN between 2010 and 2017.
View Article and Find Full Text PDFAm J Physiol Endocrinol Metab
March 2025
Department of Kinesiology, East Carolina University, Greenville, North Carolina, United States.
Offspring exposed to metformin treatment for gestational diabetes mellitus (GDM) experience altered growth patterns that increase the risk for developing cardiometabolic diseases later in life. The adaptive cellular mechanisms underlying these patterns remain unclear. Therefore, the objective of this study was to determine if chronic metformin exposure associated with GDM treatment elicits infant cellular metabolic adaptations.
View Article and Find Full Text PDFCancer
March 2025
Department of Oncology, Karmanos Cancer Institute at Wayne State University, Detroit, Michigan, USA.
Background: Prior studies of participants with breast and other obesity-associated cancers in the Women's Health Initiative (WHI) showed worse mortality and cardiovascular disease (CVD) outcomes for individuals with a higher number of cardiometabolic risk factors at study entry. The purpose of this analysis is to compare the relationship between cardiometabolic abnormalities and mortality among women with and without cancer in the WHI.
Methods: Women with one of five early-stage obesity-associated cancers (breast, colorectal, endometrial, ovarian, and non-Hodgkin lymphoma) and controls without any new or prior history of cancer were selected from the WHI-Life and Longevity after Cancer ancillary study.
Obes Surg
March 2025
Addiction Unit, Clinical Institute of Neurosciences (ICN), Hospital Clinic of Barcelona, C/Villarroel, 170, 08036, Barcelona, Spain.
Unlabelled: Following bariatric surgery (BS) patients have an increased risk of alcohol misuse.
Purpose: This 1-year cross-sectional study in potential BS candidates had several objectives: (a) assess the prevalence of risky drinking, alcohol use disorder (AUD), and other substance use/disorder; (b) compare the prevalence of these behaviors to that of the general Spanish population; (c) determine the proportion of patients with positive results in toxicology tests; and (d) study the predictive factors of risky drinking.
Setting: tertiary university hospital.
Eur J Nutr
March 2025
Department of Nutrition and Food Safety, West China School of Public Health, West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, China.
Background: Few studies have examined the association between lactating behaviors and postpartum weight retention (PPWR) during the 'Zuòyuèzi' period, a traditional Chinese postpartum confinement practice that typically occurs within the first month after delivery. This study aimed to examine the association between breastfeeding practices (exclusive vs. mixed feeding) and PPWR during the Zuòyuèzi period; and to explore the feasibility of the new latent category variable derived from latent class analysis (LCA) reflecting lactating experience and quality.
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